tert-butyl (3S)-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

Base Information

Chemical Name:tert-butyl (3S)-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate
CAS No.:1606140-40-2
Molecular Formula:C₂₇H₃₉NO₄
Molecular Weight:441.611
Hs Code.:

Synonyms:tert-butyl (3S)-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

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Chemical Property of tert-butyl (3S)-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

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Technology Process of tert-butyl (3S)-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

There total 3 articles about tert-butyl (3S)-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1606140-38-8
tert-butyl (E)-4,4-diethoxybut-2-enoate

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 1606140-40-2
tert-butyl (3S)-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

tert-butyl (E)-4,4-diethoxybut-2-enoate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.25h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2014.03.055

Reference yield:

: 3054-95-3
acrylaldehyde diethyl acetal

: 1606140-40-2
tert-butyl (3S)-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 22 h / Reflux; Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

2.3: 0.25 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; Hoveyda-Grubbs catalyst second generation; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2014.03.055

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1606140-40-2
tert-butyl (3S)-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 22 h / Reflux; Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

2.3: 0.25 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; Hoveyda-Grubbs catalyst second generation; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2014.03.055