Technology Process of 5-[2-[1-[(1,1-Dimethylethoxy)carbonyl]-4-piperidinyl]ethyl]-5,6,7,8-tetrahydro-4-oxo-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxylic acid
There total 11 articles about 5-[2-[1-[(1,1-Dimethylethoxy)carbonyl]-4-piperidinyl]ethyl]-5,6,7,8-tetrahydro-4-oxo-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
tetrahydrofuran;
for 18h;
Ambient temperature;
DOI:10.1021/jm9608117
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / HCl(g) / 2 h / Heating
2: 78 percent / K2CO3 / acetonitrile / 0.42 h / Heating
3: 95 percent / NaN3 / dimethylsulfoxide / 16 h / 25 °C
4: H2, HCl(g) / 10percent Pd/C / methanol / 5 h / 2327.2 Torr
5: Et3N / methanol / 1.5 h / Heating
6: 1.) NaH / 1.) DMF, -15 deg C, 30 min, 2.) DMF, RT, overnight
7: 99 percent / 1N aq. LiOH / tetrahydrofuran / 18 h / Ambient temperature
With
hydrogenchloride; lithium hydroxide; sodium azide; hydrogen; sodium hydride; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm9608117
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 78 percent / K2CO3 / acetonitrile / 0.42 h / Heating
2: 95 percent / NaN3 / dimethylsulfoxide / 16 h / 25 °C
3: H2, HCl(g) / 10percent Pd/C / methanol / 5 h / 2327.2 Torr
4: Et3N / methanol / 1.5 h / Heating
5: 1.) NaH / 1.) DMF, -15 deg C, 30 min, 2.) DMF, RT, overnight
6: 99 percent / 1N aq. LiOH / tetrahydrofuran / 18 h / Ambient temperature
With
hydrogenchloride; lithium hydroxide; sodium azide; hydrogen; sodium hydride; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm9608117
![5-[2-(1-tert-Butoxycarbonyl-piperidin-4-yl)-ethyl]-4-oxo-5,6,7,8-tetrahydro-4H-1,5,8a-triaza-azulene-2-carboxylic acid methyl ester](/Databaselist/images/loading.webp)
