(34A) 1-{6-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]pyridin-3-yl}-3-(trityloxy)propyl acetate

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Chemical Name:(34A) 1-{6-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]pyridin-3-yl}-3-(trityloxy)propyl acetate
CAS No.:1202577-35-2
Molecular Formula:C₄₄H₄₁NO₄
Molecular Weight:647.814
Hs Code.:

Synonyms:(34A) 1-{6-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]pyridin-3-yl}-3-(trityloxy)propyl acetate

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Chemical Property of (34A) 1-{6-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]pyridin-3-yl}-3-(trityloxy)propyl acetate

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Technology Process of (34A) 1-{6-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]pyridin-3-yl}-3-(trityloxy)propyl acetate

There total 6 articles about (34A) 1-{6-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]pyridin-3-yl}-3-(trityloxy)propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1202577-27-2
1-{6-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]pyridin-3-yl}-3-(trityloxy)propan-1-ol

: 108-24-7
acetic anhydride

: 1202577-35-2
(34A) 1-{6-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]pyridin-3-yl}-3-(trityloxy)propyl acetate

Guidance literature:: With pyridine; at 0 - 65 ℃; Inert atmosphere;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1202577-35-2
(34A) 1-{6-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]pyridin-3-yl}-3-(trityloxy)propyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 3 h / 60 °C / Inert atmosphere

2.1: n-butyllithium / hexane; diethyl ether / 0.83 h / -78 °C / Inert atmosphere

2.2: -78 - 0 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: 1.5 h / -78 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.3: 12 h / 20 °C / Inert atmosphere

5.1: pyridine / 0 - 65 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; n-butyllithium; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;

Reference yield:

: 691905-27-8
(2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methanol

: 1202577-35-2
(34A) 1-{6-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]pyridin-3-yl}-3-(trityloxy)propyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 3 h / 60 °C / Inert atmosphere

2.1: n-butyllithium / hexane; diethyl ether / 0.83 h / -78 °C / Inert atmosphere

2.2: -78 - 0 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: 1.5 h / -78 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.3: 12 h / 20 °C / Inert atmosphere

5.1: pyridine / 0 - 65 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; n-butyllithium; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;