ethyl 3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl phenylphosphonate

Base Information

Chemical Name:ethyl 3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl phenylphosphonate
CAS No.:1606168-30-2
Molecular Formula:C₂₄H₂₁N₄O₅P
Molecular Weight:476.428
Hs Code.:

Synonyms:ethyl 3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl phenylphosphonate

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Chemical Property of ethyl 3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl phenylphosphonate

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Technology Process of ethyl 3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl phenylphosphonate

There total 5 articles about ethyl 3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1606168-15-3
3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenol

: 5284-12-8
ethyl chloro(phenyl)phosphinate

: 1606168-30-2
ethyl 3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl phenylphosphonate

Guidance literature:: 3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenol; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

ethyl chloro(phenyl)phosphinate; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm401742r

Reference yield:

: 915069-51-1
4-chloro-6-(3-nitrophenyl)-pyrimidine

: 1606168-30-2
ethyl 3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl phenylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm401742r

Reference yield:

: 591-27-5
m-Hydroxyaniline

: 1606168-30-2
ethyl 3-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl phenylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm401742r