(2S,3S)-N-(4-bromobenzyl)-N,N,3-trimethyl-2-(3-(4-nitrophenyl)thioureido)pentan-1-ammonium bromide

Base Information

Chemical Name:(2S,3S)-N-(4-bromobenzyl)-N,N,3-trimethyl-2-(3-(4-nitrophenyl)thioureido)pentan-1-ammonium bromide
CAS No.:1438263-85-4
Molecular Formula:Br*C₂₂H₃₀BrN₄O₂S
Molecular Weight:574.38
Hs Code.:

Synonyms:(2S,3S)-N-(4-bromobenzyl)-N,N,3-trimethyl-2-(3-(4-nitrophenyl)thioureido)pentan-1-ammonium bromide

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Chemical Property of (2S,3S)-N-(4-bromobenzyl)-N,N,3-trimethyl-2-(3-(4-nitrophenyl)thioureido)pentan-1-ammonium bromide

Chemical Property:

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Technology Process of (2S,3S)-N-(4-bromobenzyl)-N,N,3-trimethyl-2-(3-(4-nitrophenyl)thioureido)pentan-1-ammonium bromide

There total 5 articles about (2S,3S)-N-(4-bromobenzyl)-N,N,3-trimethyl-2-(3-(4-nitrophenyl)thioureido)pentan-1-ammonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-((2S,3S)-1-(dimethylamino)-3-methylpentan-2-yl)-3-(4-nitrophenyl)thiourea

: 589-15-1
1-bromomethyl-4-bromobenzene

: 1438263-85-4
(2S,3S)-N-(4-bromobenzyl)-N,N,3-trimethyl-2-(3-(4-nitrophenyl)thioureido)pentan-1-ammonium bromide

Guidance literature:: In acetonitrile; at 20 ℃;
DOI:10.1016/j.tet.2013.04.079

Reference yield:

: 192821-24-2
(2S,3S)-tert-butyl 1-(dimethylamino)-3-methyl-1-oxopentan-2-ylcarbamate

: 1438263-85-4
(2S,3S)-N-(4-bromobenzyl)-N,N,3-trimethyl-2-(3-(4-nitrophenyl)thioureido)pentan-1-ammonium bromide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 75 °C

3: dichloromethane

4: acetonitrile / 20 °C

With lithium aluminium tetrahydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.04.079

Reference yield:

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 1438263-85-4
(2S,3S)-N-(4-bromobenzyl)-N,N,3-trimethyl-2-(3-(4-nitrophenyl)thioureido)pentan-1-ammonium bromide

Guidance literature:: Multi-step reaction with 5 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 75 °C

4: dichloromethane

5: acetonitrile / 20 °C

With lithium aluminium tetrahydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.04.079