4-(2-methylcyclohexyloxy)-6-phenethyl pyridin-2(1H)-one

Base Information

• Chemical Name: 4-(2-methylcyclohexyloxy)-6-phenethyl pyridin-2(1H)-one
• CAS No.: 1430415-03-4
• Molecular Formula: C₂₀H₂₅NO₂
• Molecular Weight: 311.424
• Mol file: 1430415-03-4.mol

Synonyms:4-(2-methylcyclohexyloxy)-6-phenethyl pyridin-2(1H)-one

Chemical Property of 4-(2-methylcyclohexyloxy)-6-phenethyl pyridin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-methylcyclohexyloxy)-6-phenethyl pyridin-2(1H)-one

There total 9 articles about 4-(2-methylcyclohexyloxy)-6-phenethyl pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

C23H29NO4 → 4-(2-methylcyclohexyloxy)-6-phenethyl pyridin-2(1H)-one (1430415-03-4)

Guidance literature:

With hydrogenchloride; In water; for 48h; Reflux;

DOI:10.1021/jm400102x

Reference yield: 45.0%

ethyl 2-(benzyloxy)-4-(2-methylcyclohexyloxy)-6-phenethyl nicotinate (1430415-02-3) → 4-(2-methylcyclohexyloxy)-6-phenethyl pyridin-2(1H)-one (1430415-03-4)

Guidance literature:

With hydrogenchloride; In water; for 36h; Reflux;

DOI:10.1039/c5ob02154e

Reference yield:

ethyl 2-(benzyloxy)-4-hydroxy-6-phenethylnicotinate (1282619-52-6) → 4-(2-methylcyclohexyloxy)-6-phenethyl pyridin-2(1H)-one (1430415-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C / 775.74 Torr

3: hydrogenchloride / water / 48 h / Reflux

With hydrogenchloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; triphenylphosphine; In tetrahydrofuran; methanol; water;

DOI:10.1021/jm400102x

upstream raw materials:

hydrocinnamic acid chloride

ethyl 3-amino-5-phenylpent-2-enoate

ethyl 4-hydroxy-2-oxo-6-phenethyl-1,2-dihydropyridine-3-carboxylate

ethyl 2-(benzyloxy)-4-hydroxy-6-phenethylnicotinate

Refernces

• 1、 Li, Amin,Ouyang, Yabo,Wang, Ziyun,Cao, Yuanyuan,Liu, Xiangyi,Ran, Li,Li, Chao,Li, Li,Zhang, Liang,Qiao, Kang,Xu, Weisi,Huang, Yang,Zhang, Zhili,Tian, Chao,Liu, Zhenming,Jiang, Shibo,Shao, Yiming,Du, Yansheng,Ma, Liying,Wang, Xiaowei,Liu, Junyi. "Novel pyridinone derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) with high potency against NNRTI-resistant HIV-1 strains". . p. 3593 - 3608. Retrieved 2013/06/27.