(E)-3-(4-chlorophenyl)-N-(2-(4-(2-hydroxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Base Information

Chemical Name:(E)-3-(4-chlorophenyl)-N-(2-(4-(2-hydroxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide
CAS No.:1374856-25-3
Molecular Formula:C₂₅H₂₆ClN₅O₃
Molecular Weight:479.966
Hs Code.:

Synonyms:(E)-3-(4-chlorophenyl)-N-(2-(4-(2-hydroxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Suppliers and Price of (E)-3-(4-chlorophenyl)-N-(2-(4-(2-hydroxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-(4-chlorophenyl)-N-(2-(4-(2-hydroxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-(4-chlorophenyl)-N-(2-(4-(2-hydroxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

There total 14 articles about (E)-3-(4-chlorophenyl)-N-(2-(4-(2-hydroxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24393-52-0
ethyl (E)-3-(4-chlorophenyl)prop-2-enoate

: 1374856-25-3
(E)-3-(4-chlorophenyl)-N-(2-(4-(2-hydroxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / methanol / 16 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride / dichloromethane / 3 h / 0 - 20 °C

With tetrabutyl ammonium fluoride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.03.049

Reference yield:

: C₃₁H₄₀ClN₅O₃Si

: 1374856-25-3
(E)-3-(4-chlorophenyl)-N-(2-(4-(2-hydroxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Guidance literature:: With tetrabutyl ammonium fluoride; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2012.03.049

Reference yield:

: 850172-44-0
2-chloro-4-methyl-6-nitroquinazoline

: 1374856-25-3
(E)-3-(4-chlorophenyl)-N-(2-(4-(2-hydroxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / methanol / 2 h / Reflux

2: 1H-imidazole / dichloromethane / 24 h / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 2 h

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 0 - 20 °C

5: tetrabutyl ammonium fluoride / dichloromethane / 3 h / 0 - 20 °C

With 1H-imidazole; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.03.049