(R,S)-ethyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxo-propanoylamino}propanoate

Base Information

Chemical Name:(R,S)-ethyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxo-propanoylamino}propanoate
CAS No.:403600-01-1
Molecular Formula:C₂₄H₂₈N₄O₅
Molecular Weight:452.51
Hs Code.:

Synonyms:(R,S)-ethyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxo-propanoylamino}propanoate

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Chemical Property of (R,S)-ethyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxo-propanoylamino}propanoate

Chemical Property:

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Technology Process of (R,S)-ethyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxo-propanoylamino}propanoate

There total 4 articles about (R,S)-ethyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxo-propanoylamino}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19727-83-4
6-nitroindoline

: 403600-01-1
(R,S)-ethyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxo-propanoylamino}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / Et₃N / CHCl₃ / 14 h / 20 °C

2: 1.51 g / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 760 Torr

3: 92 percent / acetonitrile / 12 h / 20 °C

4: 1.91 g / 1 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C

5: 78 percent / HOBt; EDC; Et₃N / dimethylformamide / 17 h / 20 °C

With sodium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.49.1420

Reference yield:

: 229636-36-6
ethyl 3-(6-nitroindolin-1-yl)-3-oxopropanoate

: 403600-01-1
(R,S)-ethyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxo-propanoylamino}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.51 g / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 760 Torr

2: 92 percent / acetonitrile / 12 h / 20 °C

3: 1.91 g / 1 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C

4: 78 percent / HOBt; EDC; Et₃N / dimethylformamide / 17 h / 20 °C

With sodium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.49.1420

Reference yield:

: 229636-37-7
ethyl 3-(6-aminoindolin-1-yl)-3-oxopropanoate

: 403600-01-1
(R,S)-ethyl 3-{3-[6-(3-benzylureido)indolin-1-yl]-3-oxo-propanoylamino}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / acetonitrile / 12 h / 20 °C

2: 1.91 g / 1 M aq. NaOH / methanol; tetrahydrofuran / 2 h / 20 °C

3: 78 percent / HOBt; EDC; Et₃N / dimethylformamide / 17 h / 20 °C

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.49.1420