methyl 8-(4-amino-2,5-difluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

Base Information

Chemical Name:methyl 8-(4-amino-2,5-difluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate
CAS No.:1371630-25-9
Molecular Formula:C₂₁H₁₈F₂N₂O₃
Molecular Weight:384.382
Hs Code.:

Synonyms:methyl 8-(4-amino-2,5-difluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

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Chemical Property of methyl 8-(4-amino-2,5-difluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

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Technology Process of methyl 8-(4-amino-2,5-difluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

There total 9 articles about methyl 8-(4-amino-2,5-difluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 939807-75-7
2,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1371629-97-8
methyl 8-chloro-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

: 1371630-25-9
methyl 8-(4-amino-2,5-difluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; toluene; at 90 ℃; for 4h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 112279-60-4
4-bromo-2,5-difluoroaniline

: 1371630-25-9
methyl 8-(4-amino-2,5-difluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 16 h / 90 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol; water / 4 h / 90 °C / Inert atmosphere

With potassium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; ethanol; water; toluene; 2: Suzuki Coupling;

Reference yield:

: (3-methyl-4-chloropyridin-2-yl)cyclopropylmethanol

: 1371630-25-9
methyl 8-(4-amino-2,5-difluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 0 °C

2.2: 40 °C

3.1: sulfuric acid; acetic acid / 20 °C

3.2: pH 8 - 9

4.1: piperidine; acetic acid / ethanol / 5 h / 100 °C

5.1: diphenyl ether-biphenyl eutectic / 0.5 h / 240 °C / microwave irradiation

6.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol; water / 4 h / 90 °C / Inert atmosphere

With piperidine; manganese(IV) oxide; sulfuric acid; sodium hydride; sodium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; diphenyl ether-biphenyl eutectic; ethanol; dichloromethane; water; toluene; mineral oil; 6.1: Suzuki Coupling;