(1S,1'R)-9-benzyl-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydropyrido<3,4-b>indole

Base Information

Chemical Name:(1S,1'R)-9-benzyl-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydropyrido<3,4-b>indole
CAS No.:142605-16-1
Molecular Formula:C₃₂H₃₀N₂O
Molecular Weight:458.603
Hs Code.:

Synonyms:(1S,1'R)-9-benzyl-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydropyrido<3,4-b>indole

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Chemical Property of (1S,1'R)-9-benzyl-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydropyrido<3,4-b>indole

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Technology Process of (1S,1'R)-9-benzyl-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydropyrido<3,4-b>indole

There total 5 articles about (1S,1'R)-9-benzyl-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydropyrido<3,4-b>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: phenylmagnesium bromide

: 142605-18-3
(3R,11bS)-11-benzyl-3-phenyl-2,3,5,6-tetrahydro-11bH-oxazolo-<3',2':1,2>pyrido<3,4-b>indole

: 142605-16-1
(1S,1'R)-9-benzyl-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydropyrido<3,4-b>indole

Guidance literature:: In diethyl ether; at -78 ℃; for 3h;
DOI:10.1248/cpb.39.3338

Reference yield:

: 14602-03-0
1-benzyl-3-(2-hydroxyethyl)indole

: 142605-16-1
(1S,1'R)-9-benzyl-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydropyrido<3,4-b>indole

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / diethyl ether / 3 h / Ambient temperature

2: 49 percent / POCl₃ / 5 h / 50 °C

3: tetrahydrofuran; diethyl ether / 0.5 h / Ambient temperature

4: Et₃N / CHCl₃ / 2 h / 0 °C

5: 77 percent / diethyl ether / 3 h / -78 °C

With triethylamine; trichlorophosphate; In tetrahydrofuran; diethyl ether; chloroform;
DOI:10.1248/cpb.39.3338

Reference yield:

: 125923-36-6
1-benzyl-3-(2-bromoethyl)indole

: 142605-16-1
(1S,1'R)-9-benzyl-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydropyrido<3,4-b>indole

Guidance literature:: Multi-step reaction with 4 steps

1: 49 percent / POCl₃ / 5 h / 50 °C

2: tetrahydrofuran; diethyl ether / 0.5 h / Ambient temperature

3: Et₃N / CHCl₃ / 2 h / 0 °C

4: 77 percent / diethyl ether / 3 h / -78 °C

With triethylamine; trichlorophosphate; In tetrahydrofuran; diethyl ether; chloroform;
DOI:10.1248/cpb.39.3338