5‐methyl‐2‐(4‐phenylthiazol‐2‐yl)‐1,2‐dihydro‐3H‐pyrazol‐3‐one

Base Information

• Chemical Name: 5‐methyl‐2‐(4‐phenylthiazol‐2‐yl)‐1,2‐dihydro‐3H‐pyrazol‐3‐one
• CAS No.: 129302-12-1
• Molecular Formula: C₁₃H₁₁N₃OS
• Molecular Weight: 257.316
• Mol file: 129302-12-1.mol

Synonyms:5‐methyl‐2‐(4‐phenylthiazol‐2‐yl)‐1,2‐dihydro‐3H‐pyrazol‐3‐one

Chemical Property of 5‐methyl‐2‐(4‐phenylthiazol‐2‐yl)‐1,2‐dihydro‐3H‐pyrazol‐3‐one

Chemical Property:

Purity/Quality:

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Technology Process of 5‐methyl‐2‐(4‐phenylthiazol‐2‐yl)‐1,2‐dihydro‐3H‐pyrazol‐3‐one

There total 1 articles about 5‐methyl‐2‐(4‐phenylthiazol‐2‐yl)‐1,2‐dihydro‐3H‐pyrazol‐3‐one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-hydrazino-4-phenylthiazole (34176-52-8) + ethyl acetoacetate (141-97-9) → 5‐methyl‐2‐(4‐phenylthiazol‐2‐yl)‐1,2‐dihydro‐3H‐pyrazol‐3‐one (129302-12-1)

Guidance literature:

ethyl acetoacetate; With N,N-dimethyl-formamide dimethyl acetal; at 100 ℃;

2-hydrazino-4-phenylthiazole; In ethanol; for 2h; Reflux;

DOI:10.1002/ardp.202000140

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 5‐methyl‐2‐(4‐phenylthiazol‐2‐yl)‐1,2‐dihydro‐3H‐pyrazol‐3‐one (129302-12-1) → 1,5-dimethyl-2-(4-phenyl-thiazol-2-yl)-1,2-dihydro-pyrazol-3-one

Guidance literature:

With diethyl ether;

DOI:10.1002/ardp.19532860104

Reference yield:

5‐methyl‐2‐(4‐phenylthiazol‐2‐yl)‐1,2‐dihydro‐3H‐pyrazol‐3‐one (129302-12-1) + dimethyl sulfate (77-78-1) → 1,5-dimethyl-2-(4-phenyl-thiazol-2-yl)-1,2-dihydro-pyrazol-3-one

Guidance literature:

With sodium hydroxide;

DOI:10.1002/ardp.19532860104

upstream raw materials:

2-hydrazino-4-phenylthiazole

ethyl acetoacetate