[2-(1H-Imidazole-2-sulfinylmethyl)-4-trifluoromethoxy-phenyl]-isobutyl-amine

Base Information

Chemical Name:[2-(1H-Imidazole-2-sulfinylmethyl)-4-trifluoromethoxy-phenyl]-isobutyl-amine
CAS No.:128936-27-6
Molecular Formula:C₁₅H₁₈F₃N₃O₂S
Molecular Weight:361.388
Hs Code.:

Synonyms:[2-(1H-Imidazole-2-sulfinylmethyl)-4-trifluoromethoxy-phenyl]-isobutyl-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-(1H-Imidazole-2-sulfinylmethyl)-4-trifluoromethoxy-phenyl]-isobutyl-amine

Chemical Property:

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Technology Process of [2-(1H-Imidazole-2-sulfinylmethyl)-4-trifluoromethoxy-phenyl]-isobutyl-amine

There total 5 articles about [2-(1H-Imidazole-2-sulfinylmethyl)-4-trifluoromethoxy-phenyl]-isobutyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 128936-26-5
[2-(1H-Imidazol-2-ylsulfanylmethyl)-4-trifluoromethoxy-phenyl]-isobutyl-amine

: 128936-27-6
[2-(1H-Imidazole-2-sulfinylmethyl)-4-trifluoromethoxy-phenyl]-isobutyl-amine

Guidance literature:: With ammonium metavanadate; dihydrogen peroxide; acetic acid; In methanol; chloroform; at -3 - 3 ℃; for 2.5h;
DOI:10.1248/cpb.40.675

Reference yield:

: 141541-83-5
(2-Isobutylamino-5-trifluoromethoxy-phenyl)-methanol

: 128936-27-6
[2-(1H-Imidazole-2-sulfinylmethyl)-4-trifluoromethoxy-phenyl]-isobutyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂ / 0.5 h / 0 °C

2: ethanol / 1 h / Ambient temperature

3: 65 percent / AcOH, 35percent aq. H₂O₂, NH₄VO₃ / CHCl₃; methanol / 2.5 h / -3 - 3 °C

With ammonium metavanadate; thionyl chloride; dihydrogen peroxide; acetic acid; In methanol; ethanol; dichloromethane; chloroform;
DOI:10.1248/cpb.40.675

Reference yield:

: 2-amino-5-trifluoromethoxy-benzoic acid methyl ester

: 128936-27-6
[2-(1H-Imidazole-2-sulfinylmethyl)-4-trifluoromethoxy-phenyl]-isobutyl-amine

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / benzene / 2 h / Heating

2: LiAlH₄ / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 50 deg C, 1 h

3: SOCl₂ / CH₂Cl₂ / 0.5 h / 0 °C

4: ethanol / 1 h / Ambient temperature

5: 65 percent / AcOH, 35percent aq. H₂O₂, NH₄VO₃ / CHCl₃; methanol / 2.5 h / -3 - 3 °C

With ammonium metavanadate; lithium aluminium tetrahydride; thionyl chloride; dihydrogen peroxide; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; benzene;
DOI:10.1248/cpb.40.675