8-chloro-3-(5-O-trityl-2,3-O-isopropylidene-β-D-ribofuranosyl)imidazo<1,2-a>pyrazine

Base Information

Chemical Name:8-chloro-3-(5-O-trityl-2,3-O-isopropylidene-β-D-ribofuranosyl)imidazo<1,2-a>pyrazine
CAS No.:142588-95-2
Molecular Formula:C₃₃H₃₀ClN₃O₄
Molecular Weight:568.072
Hs Code.:

Synonyms:8-chloro-3-(5-O-trityl-2,3-O-isopropylidene-β-D-ribofuranosyl)imidazo<1,2-a>pyrazine

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Chemical Property of 8-chloro-3-(5-O-trityl-2,3-O-isopropylidene-β-D-ribofuranosyl)imidazo<1,2-a>pyrazine

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Technology Process of 8-chloro-3-(5-O-trityl-2,3-O-isopropylidene-β-D-ribofuranosyl)imidazo<1,2-a>pyrazine

There total 5 articles about 8-chloro-3-(5-O-trityl-2,3-O-isopropylidene-β-D-ribofuranosyl)imidazo<1,2-a>pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86563-14-6,86563-15-7,142695-06-5
methyl (2ξ)-3,6-anhydro-2-deoxy-2-bromo-4,5-O-isopropylidene-7-O-trityl-D-allo-heptonate

: 142588-95-2
8-chloro-3-(5-O-trityl-2,3-O-isopropylidene-β-D-ribofuranosyl)imidazo<1,2-a>pyrazine

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / lithium borohydride / tetrahydrofuran / 0.5 h

2: 96 percent / sodium hydride / dimethylformamide / Ambient temperature

3: 82 percent / NH₃, methanol / 2 h / 100 °C

4: 40 percent / triethylamine / dioxane / Heating

5: 55 percent / trifluoroacetic anhydride, dimethyl sulfoxide / CH₂Cl₂ / 1.33 h / Ambient temperature

6: 64 percent / pyridine, trifluoroacetic acid, trifluoroacetic anhydride / toluene / 1.) 0 deg C, 30 min, 2.) RT, overnight

With pyridine; methanol; lithium borohydride; ammonia; sodium hydride; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.5570300508

Reference yield:

: (2ξ)-3,6-anhydro-2-bromo-2-deoxy-4,5-O-isopropylidene-7-O-trityl-D-allo-heptitol

: 142588-95-2
8-chloro-3-(5-O-trityl-2,3-O-isopropylidene-β-D-ribofuranosyl)imidazo<1,2-a>pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / sodium hydride / dimethylformamide / Ambient temperature

2: 82 percent / NH₃, methanol / 2 h / 100 °C

3: 40 percent / triethylamine / dioxane / Heating

4: 55 percent / trifluoroacetic anhydride, dimethyl sulfoxide / CH₂Cl₂ / 1.33 h / Ambient temperature

5: 64 percent / pyridine, trifluoroacetic acid, trifluoroacetic anhydride / toluene / 1.) 0 deg C, 30 min, 2.) RT, overnight

With pyridine; methanol; ammonia; sodium hydride; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.5570300508

Reference yield:

: (2ξ)-1-amino-3,6-anhydro-1-deoxy-4,5-O-isopropylidene-7-O-trityl-D-allo-heptitol

: 142588-95-2
8-chloro-3-(5-O-trityl-2,3-O-isopropylidene-β-D-ribofuranosyl)imidazo<1,2-a>pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / triethylamine / dioxane / Heating

2: 55 percent / trifluoroacetic anhydride, dimethyl sulfoxide / CH₂Cl₂ / 1.33 h / Ambient temperature

3: 64 percent / pyridine, trifluoroacetic acid, trifluoroacetic anhydride / toluene / 1.) 0 deg C, 30 min, 2.) RT, overnight

With pyridine; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In 1,4-dioxane; dichloromethane; toluene;
DOI:10.1002/jhet.5570300508