(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3S)-3-propyl-oxiranylmethyl ester

Base Information

Chemical Name:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3S)-3-propyl-oxiranylmethyl ester
CAS No.:89321-72-2
Molecular Formula:C₁₆H₁₉F₃O₄
Molecular Weight:332.32
Hs Code.:

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3S)-3-propyl-oxiranylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3S)-3-propyl-oxiranylmethyl ester

Chemical Property:

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Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3S)-3-propyl-oxiranylmethyl ester

There total 4 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3S)-3-propyl-oxiranylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 89321-71-1
(2S,3S)-3-propyl-2-oxiranemethanol

: 89321-72-2
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3S)-3-propyl-oxiranylmethyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1.5h; Sealed tube;
DOI:10.15227/orgsyn.063.0066

Reference yield:

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 89321-71-1
(2S,3S)-3-propyl-2-oxiranemethanol

: 89321-72-2
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3S)-3-propyl-oxiranylmethyl ester

Guidance literature:: With pyridine; 1) RT, 6 h; 2) refrigerator 14 h;
DOI:10.1021/jo00183a007

Reference yield:

: 928-95-0
(E)-2-Hexen-1-ol

: 89321-72-2
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3S)-3-propyl-oxiranylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butylhydroperoxide; titanium(IV) isopropylate; diethyl (2R,3R)-tartrate / dichloromethane; toluene / 2 h / -70 - 0 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 1.5 h / 20 °C / Sealed tube

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; diethyl (2R,3R)-tartrate; triethylamine; In dichloromethane; toluene;
DOI:10.15227/orgsyn.063.0066