6-AMINOMETHYL INDAZOLE

Base Information

• Chemical Name: 6-AMINOMETHYL INDAZOLE
• CAS No.: 710943-26-3
• Molecular Formula: C8H9N3
• Molecular Weight: 147.18
• Hs Code.: 2933990090
• Mol file: 710943-26-3.mol

Synonyms:6-AMINOMETHYL INDAZOLE;6-aminomethyl-1H-indazole;(1H-indazol-6-yl)methanamine;1-(1H-indazol-6-yl)methanamine;(1H-Indazol-6-yl)methylamine

Chemical Property of 6-AMINOMETHYL INDAZOLE

Chemical Property:

• Vapor Pressure: 3.93E-05mmHg at 25°C
• Refractive Index: 1.712
• Boiling Point: 352.1 °C at 760 mmHg
• PKA: 14.27±0.40(Predicted)
• Flash Point: 193.8 °C
• PSA: 54.70000
• Density: 1.278 g/cm³
• LogP: 1.72190
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

(1H-indazol-6-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-AMINOMETHYL INDAZOLE

There total 2 articles about 6-AMINOMETHYL INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1H-indazole-6-carbonitrile (141290-59-7) → (1H-indazol-6-yl)methanamine (710943-26-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere; Reflux;

DOI:10.1002/cmdc.201600204

Reference yield:

C8H7N3O → (1H-indazol-6-yl)methanamine (710943-26-3)

Guidance literature:

With hydrogen; palladium on carbon; under 2327.23 Torr;

Reference yield: 62.0%

(1H-indazol-6-yl)methanamine (710943-26-3) + [3-(2-carboxyethyl)phenyl]boronic acid (693803-17-7) → (3-(3-(((1H-indazol-6-yl)methyl)amino)-3-oxopropyl)phenyl)boronic acid

Guidance literature:

[3-(2-carboxyethyl)phenyl]boronic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 23 ℃; for 0.0833333h;

(1H-indazol-6-yl)methanamine; In N,N-dimethyl-formamide; at 23 ℃;

DOI:10.1021/acsmedchemlett.0c00011

upstream raw materials:

1H-indazole-6-carbonitrile

Downstream raw materials:

6-(2,3-dimethylphenyl)-4-N-(1H-indazol-6-ylmethyl)pyrimidine-2,4-diamine