N-[(N-tert-butoxycarbonyl-N-methyl)glycyl]-N-[2-(N⁶-benzyloxycarbonyladenyn-9-yl)ethyl]glycine methyl ester

Base Information

• Chemical Name: N-[(N-tert-butoxycarbonyl-N-methyl)glycyl]-N-[2-(N⁶-benzyloxycarbonyladenyn-9-yl)ethyl]glycine methyl ester
• CAS No.: 344414-14-8
• Molecular Formula: C₂₆H₃₃N₇O₇
• Molecular Weight: 555.591

Synonyms:N-[(N-tert-butoxycarbonyl-N-methyl)glycyl]-N-[2-(N⁶-benzyloxycarbonyladenyn-9-yl)ethyl]glycine methyl ester

Chemical Property of N-[(N-tert-butoxycarbonyl-N-methyl)glycyl]-N-[2-(N⁶-benzyloxycarbonyladenyn-9-yl)ethyl]glycine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(N-tert-butoxycarbonyl-N-methyl)glycyl]-N-[2-(N⁶-benzyloxycarbonyladenyn-9-yl)ethyl]glycine methyl ester

There total 5 articles about N-[(N-tert-butoxycarbonyl-N-methyl)glycyl]-N-[2-(N⁶-benzyloxycarbonyladenyn-9-yl)ethyl]glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-(tert-butoxycarbonyl)sarcosine (13734-36-6) + N-[2-(N6-benzyloxycarbonyladenin-9-yl)-ethyl]glycine methyl ester (344414-10-4) → N-[(N-tert-butoxycarbonyl-N-methyl)glycyl]-N-[2-(N6-benzyloxycarbonyladenyn-9-yl)ethyl]glycine methyl ester (344414-14-8)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0040-4020(01)00182-X

Reference yield:

adenine (66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9) → N-[(N-tert-butoxycarbonyl-N-methyl)glycyl]-N-[2-(N6-benzyloxycarbonyladenyn-9-yl)ethyl]glycine methyl ester (344414-14-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 27 percent / triphenylphosphine; DEAD / tetrahydrofuran / 20 °C

2: 75 percent / triethyloxonium tetrafluoroborate / CH₂Cl₂ / 20 °C

3: TFA / CH₂Cl₂ / 20 °C

4: 65 percent / HBTU; DIPEA / dimethylformamide / 20 °C

With triethyloxonium fluoroborate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Mitsunobu reaction;

DOI:10.1016/S0040-4020(01)00182-X

Reference yield:

N-tert-butoxycarbonyl-N-[2-(adenin-9-yl)-ethyl]-glycine methyl ester (189160-69-8) → N-[(N-tert-butoxycarbonyl-N-methyl)glycyl]-N-[2-(N6-benzyloxycarbonyladenyn-9-yl)ethyl]glycine methyl ester (344414-14-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / triethyloxonium tetrafluoroborate / CH₂Cl₂ / 20 °C

2: TFA / CH₂Cl₂ / 20 °C

3: 65 percent / HBTU; DIPEA / dimethylformamide / 20 °C

With triethyloxonium fluoroborate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)00182-X

upstream raw materials:

N-(tert-butoxycarbonyl)sarcosine

N-[2-(N⁶-benzyloxycarbonyladenin-9-yl)-ethyl]glycine methyl ester

adenine

N-tert-Butoxycarbonyl-N-(2-hydroxyethyl)glycine methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 344414-14-8 N-[(N-tert-butoxycarbonyl-N-methyl)glycyl]-N-[2-(N⁶-benzyloxycarbonyladenyn-9-yl)ethyl]glycine methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send