(S)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

Base Information

Chemical Name:(S)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol
CAS No.:1528534-16-8
Molecular Formula:C₂₆H₃₆N₂O
Molecular Weight:392.585
Hs Code.:

Synonyms:(S)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

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Chemical Property of (S)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

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Technology Process of (S)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

There total 6 articles about (S)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1528534-34-0
methyl (S)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate

: 1528534-16-8
(S)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 16.17h; Inert atmosphere; Reflux;
DOI:10.1021/jm401707t

Reference yield:

: 1584725-27-8
methyl (S)-2-[1-benzyl-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate

: 1528534-16-8
(S)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 16.17 h / 0 °C / Inert atmosphere; Reflux

2: ammonium formate; palladium 10% on activated carbon / methanol / 3.5 h / Reflux

3: sodium tris(acetoxy)borohydride / acetonitrile

With lithium aluminium tetrahydride; palladium 10% on activated carbon; ammonium formate; sodium tris(acetoxy)borohydride; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm401707t

Reference yield:

: 1584725-21-2
dimethyl (S)-2-[N-benzyl-N-(2-chloroacetyl)amino]butanedioate

: 1528534-16-8
(S)-2-[1-(biphenyl-4-ylmethyl)-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / acetonitrile / 16 h / 20 °C / Molecular sieve

2: lithium aluminium tetrahydride / tetrahydrofuran / 16.17 h / 0 °C / Inert atmosphere; Reflux

3: ammonium formate; palladium 10% on activated carbon / methanol / 3.5 h / Reflux

4: sodium tris(acetoxy)borohydride / acetonitrile

With lithium aluminium tetrahydride; palladium 10% on activated carbon; ammonium formate; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm401707t