N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine

Base Information

Chemical Name:N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine
CAS No.:945488-77-7
Molecular Formula:C₂₈H₃₅N₃O₈
Molecular Weight:541.601
Hs Code.:

Synonyms:N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine

Suppliers and Price of N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine

There total 5 articles about N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: sodium; 3-amino-3-(3,4-dimethoxy-phenyl)-propionate

: 807627-82-3
4-[N-(t-butoxycarbonyl)-isoindoline-5-yl]amino-4-oxobutyric acid

: 945488-77-7
N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine

Guidance literature:: 4-[N-(t-butoxycarbonyl)-isoindoline-5-yl]amino-4-oxobutyric acid; With triethylamine; isobutyl chloroformate; In N,N-dimethyl-formamide; at -10 ℃; for 0.5h;

sodium; 3-amino-3-(3,4-dimethoxy-phenyl)-propionate; In N,N-dimethyl-formamide; at -10 - 20 ℃; for 2.5h;
DOI:10.1134/S1070428006080124

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 945488-77-7
N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / Na₂CO₃ / CHCl₃ / 5 h / 20 °C

2.1: hydrazine hydrate / Pd/C / dioxane / 60 °C

3.1: CHCl₃ / 0.5 h / Heating

4.1: triethylamine; isobutyl chloroformate / dimethylformamide / 0.5 h / -10 °C

4.2: 76 percent / dimethylformamide / 2.5 h / -10 - 20 °C

With sodium carbonate; hydrazine hydrate; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1134/S1070428006080124

Reference yield:

: 5-nitroisoindoline hydrobromide

: 945488-77-7
N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / Na₂CO₃ / CHCl₃ / 5 h / 20 °C

2.1: hydrazine hydrate / Pd/C / dioxane / 60 °C

3.1: CHCl₃ / 0.5 h / Heating

4.1: triethylamine; isobutyl chloroformate / dimethylformamide / 0.5 h / -10 °C

4.2: 76 percent / dimethylformamide / 2.5 h / -10 - 20 °C

With sodium carbonate; hydrazine hydrate; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1134/S1070428006080124