N³-(3-(N-(3-cyano-4-[¹⁹F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1'-methoxy-1'-cyclohexyl) thymidine

Base Information

• Chemical Name: N³-(3-(N-(3-cyano-4-[¹⁹F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1'-methoxy-1'-cyclohexyl) thymidine
• CAS No.: 1021905-41-8
• Molecular Formula: C₃₅H₄₇FN₄O₈
• Molecular Weight: 670.779

Synonyms:N³-(3-(N-(3-cyano-4-[¹⁹F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1'-methoxy-1'-cyclohexyl) thymidine

Chemical Property of N³-(3-(N-(3-cyano-4-[¹⁹F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1'-methoxy-1'-cyclohexyl) thymidine

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Technology Process of N³-(3-(N-(3-cyano-4-[¹⁹F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1'-methoxy-1'-cyclohexyl) thymidine

There total 1 articles about N³-(3-(N-(3-cyano-4-[¹⁹F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1'-methoxy-1'-cyclohexyl) thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-(3-Amino-propyl)-1-[(2R,4S,5R)-4-(1-methoxy-cyclohexyloxy)-5-(1-methoxy-cyclohexyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (1021905-52-1) + 3-cyano-4-fluorobenzoic acid (171050-06-9) → N3-(3-(N-(3-cyano-4-[19F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1'-methoxy-1'-cyclohexyl) thymidine (1021905-41-8)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 18h;

Reference yield: 50.0%

N3-(3-(N-(3-cyano-4-[19F]-fluorobenzoyl))amino-propyl)-O,O-bis-(1'-methoxy-1'-cyclohexyl) thymidine (1021905-41-8) → N3'-(3-(N-(3-cyano-4-[19F]-fluorobenzoyl))amino-propyl)-thymidine (1012868-94-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃;

upstream raw materials:

3-(3-Amino-propyl)-1-[(2R,4S,5R)-4-(1-methoxy-cyclohexyloxy)-5-(1-methoxy-cyclohexyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

3-cyano-4-fluorobenzoic acid

Downstream raw materials:

N³'-(3-(N-(3-cyano-4-[¹⁹F]-fluorobenzoyl))amino-propyl)-thymidine

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