bpy-xy-TMS

Base Information

• Chemical Name: bpy-xy-TMS
• CAS No.: 1337570-07-6
• Molecular Formula: C₂₁H₂₄N₂Si
• Molecular Weight: 332.52
• Mol file: 1337570-07-6.mol

Synonyms:bpy-xy-TMS

Chemical Property of bpy-xy-TMS

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of bpy-xy-TMS

There total 7 articles about bpy-xy-TMS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-2,2'-bipyridyl (15862-19-8) + 2,5-dimethyl-4-trimethylsilyl-1-phenylboronic acid (1059575-28-8) → bpy-xy-TMS (1337570-07-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; at 90 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jacs.8b02443

Reference yield: 47.0%

5-(tri(n-butyl)stannyl)-2,2′-bipyridine (349655-42-1) + 1-bromo-2,5-dimethyl-4-(trimethylsilyl)benzene (566181-32-6) → bpy-xy-TMS (1337570-07-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In m-xylene; for 168h; Inert atmosphere; Reflux;

DOI:10.1002/chem.201304256

Reference yield:

2-iodo-5-bromopyridine (223463-13-6) → bpy-xy-TMS (1337570-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / m-xylene / 168 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; m-xylene; 3.1: |Stille Cross Coupling;

DOI:10.1002/chem.201304256

upstream raw materials:

5-bromo-2,2'-bipyridyl

2,5-dimethyl-4-trimethylsilyl-1-phenylboronic acid

2,5-dibromo-p-xylene

1-bromo-2,5-dimethyl-4-(trimethylsilyl)benzene

Downstream raw materials:

C₃₂H₂₉N₃O₂

C₃₇H₄₀N₂Si

C₃₄H₃₁BrN₂