(3S,4R,5S)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (S)-1-carboxy-2-methyl-propyl ester

Base Information Edit

Chemical Name:(3S,4R,5S)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (S)-1-carboxy-2-methyl-propyl ester
CAS No.:250039-47-5
Molecular Formula:C₃₀H₅₁NO₇Si
Molecular Weight:565.823
Hs Code.:
Mol file:250039-47-5.mol

Synonyms:(3S,4R,5S)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (S)-1-carboxy-2-methyl-propyl ester

Suppliers and Price of (3S,4R,5S)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (S)-1-carboxy-2-methyl-propyl ester

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4R,5S)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (S)-1-carboxy-2-methyl-propyl ester Edit

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4R,5S)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (S)-1-carboxy-2-methyl-propyl ester

There total 15 articles about (3S,4R,5S)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (S)-1-carboxy-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 250039-51-1
(3S,4R,5S)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (S)-1-allyloxycarbonyl-2-methyl-propyl ester

: 250039-47-5
(3S,4R,5S)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (S)-1-carboxy-2-methyl-propyl ester

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ja010222c

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 250039-47-5
(3S,4R,5S)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (S)-1-carboxy-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.204 g / 2,6-lutidine / CH₂Cl₂ / 2.5 h / 0 - 20 °C

2: NaOH / tetrahydrofuran; methanol; H₂O / 0 - 20 °C

3: 0.5774 g / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / toluene / 0 - 20 °C

4: morpholine / Pd(PPh₃)4 / tetrahydrofuran / 20 °C

With morpholine; 2,6-dimethylpyridine; dmap; sodium hydroxide; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/ol9910058

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 250039-47-5
(3S,4R,5S)-4-Benzyloxycarbonylamino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (S)-1-carboxy-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / anhydrous potassium carbonate; tetrabutylammonium iodide / dimethylformamide / 1 h / 20 °C

2: 0.5774 g / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / toluene / 0 - 20 °C

3: morpholine / Pd(PPh₃)4 / tetrahydrofuran / 20 °C

With morpholine; dmap; tetra-(n-butyl)ammonium iodide; potassium carbonate; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol9910058