N¹,N¹-bis(2-chloroethyl)-N⁴-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)benzene-1,4-diamine

Base Information

• Chemical Name: N¹,N¹-bis(2-chloroethyl)-N⁴-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)benzene-1,4-diamine
• CAS No.: 1456621-48-9
• Molecular Formula: C₂₆H₃₃Cl₂N₅O₃
• Molecular Weight: 534.486

Synonyms:N¹,N¹-bis(2-chloroethyl)-N⁴-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)benzene-1,4-diamine

Chemical Property of N¹,N¹-bis(2-chloroethyl)-N⁴-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)benzene-1,4-diamine

Chemical Property:

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Technology Process of N¹,N¹-bis(2-chloroethyl)-N⁴-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)benzene-1,4-diamine

There total 11 articles about N¹,N¹-bis(2-chloroethyl)-N⁴-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)benzene-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-(3-chloropropyl)morpholine (7357-67-7) + 4-(4-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-ol (1456621-46-7) → N1,N1-bis(2-chloroethyl)-N4-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)benzene-1,4-diamine (1456621-48-9)

Guidance literature:

4-(4-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-ol; With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 0.333333h; Inert atmosphere;

4-(3-chloropropyl)morpholine; In N,N-dimethyl-formamide; at 80 ℃; for 4.5h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.06.055

Reference yield:

6-acetoxy-4-chloro-7-methoxyquinazoline (230955-75-6) → N1,N1-bis(2-chloroethyl)-N4-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)benzene-1,4-diamine (1456621-48-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 1 h / Inert atmosphere; Reflux

2.1: sodium hydroxide / methanol / 2 h / 40 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 40 °C / Inert atmosphere

3.2: 4.5 h / 80 °C / Inert atmosphere

With potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.ejmech.2013.06.055

Reference yield:

4-amino-N,N-bis(2-chloroethyl)aniline (2067-58-5) → N1,N1-bis(2-chloroethyl)-N4-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)benzene-1,4-diamine (1456621-48-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 1 h / Inert atmosphere; Reflux

2.1: sodium hydroxide / methanol / 2 h / 40 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 40 °C / Inert atmosphere

3.2: 4.5 h / 80 °C / Inert atmosphere

With potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.ejmech.2013.06.055

upstream raw materials:

4-amino-N,N-bis(2-chloroethyl)aniline

6-acetoxy-4-chloro-7-methoxyquinazoline

4-(4-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride

4-(3-chloropropyl)morpholine

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