(S)-N₂-[1-(4-fluorophenyl)ethyl]-6-[4-(methylsulfonyl)phenyl]-N₄-(pyrazin-2-yl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: (S)-N₂-[1-(4-fluorophenyl)ethyl]-6-[4-(methylsulfonyl)phenyl]-N₄-(pyrazin-2-yl)pyrimidine-2,4-diamine
• CAS No.: 1239358-95-2
• Molecular Formula: C₂₃H₂₁FN₆O₂S
• Molecular Weight: 464.523

Synonyms:(S)-N₂-[1-(4-fluorophenyl)ethyl]-6-[4-(methylsulfonyl)phenyl]-N₄-(pyrazin-2-yl)pyrimidine-2,4-diamine

Chemical Property of (S)-N₂-[1-(4-fluorophenyl)ethyl]-6-[4-(methylsulfonyl)phenyl]-N₄-(pyrazin-2-yl)pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of (S)-N₂-[1-(4-fluorophenyl)ethyl]-6-[4-(methylsulfonyl)phenyl]-N₄-(pyrazin-2-yl)pyrimidine-2,4-diamine

There total 3 articles about (S)-N₂-[1-(4-fluorophenyl)ethyl]-6-[4-(methylsulfonyl)phenyl]-N₄-(pyrazin-2-yl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-6-chloro-N2-[1-(4-fluorophenyl)ethyl]-N4-(pyrazin-2-yl)pyrimidine-2,4-diamine (1239358-93-0) + 4-methanesulphonylphenylboronic acid (149104-88-1) → (S)-N2-[1-(4-fluorophenyl)ethyl]-6-[4-(methylsulfonyl)phenyl]-N4-(pyrazin-2-yl)pyrimidine-2,4-diamine (1239358-95-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

(S)-1-(4-Fluoro-phenyl)-ethylamine (66399-30-2) → (S)-N2-[1-(4-fluorophenyl)ethyl]-6-[4-(methylsulfonyl)phenyl]-N4-(pyrazin-2-yl)pyrimidine-2,4-diamine (1239358-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 9.5 h / 20 °C

2: potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 100 °C

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

(S)-4,6-dichloro-N-[1-(4-fluorophenyl)ethyl]pyrimidin-2-amine (1239362-87-8) → (S)-N2-[1-(4-fluorophenyl)ethyl]-6-[4-(methylsulfonyl)phenyl]-N4-(pyrazin-2-yl)pyrimidine-2,4-diamine (1239358-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 100 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water;

upstream raw materials:

(S)-6-chloro-N₂-[1-(4-fluorophenyl)ethyl]-N₄-(pyrazin-2-yl)pyrimidine-2,4-diamine

4-methanesulphonylphenylboronic acid

(S)-1-(4-Fluoro-phenyl)-ethylamine

(S)-4,6-dichloro-N-[1-(4-fluorophenyl)ethyl]pyrimidin-2-amine

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