N-(2-hydroxycyclohexyl)-4-methoxybenzamide

Base Information

Chemical Name:N-(2-hydroxycyclohexyl)-4-methoxybenzamide
CAS No.:710290-26-9
Molecular Formula:C₁₄H₁₉NO₃
Molecular Weight:249.31
Hs Code.:
DSSTox Substance ID:DTXSID10392529
Mol file:710290-26-9.mol

Synonyms:N-(2-hydroxycyclohexyl)-4-methoxybenzamide;710290-26-9;DTXSID10392529;AKOS011650694

Suppliers and Price of N-(2-hydroxycyclohexyl)-4-methoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
BENZAMIDE, N-(2-HYDROXYCYCLOHEXYL)-4-METHOXY- 95.00%
5MG
$ 495.86

Total 2 raw suppliers

Chemical Property of N-(2-hydroxycyclohexyl)-4-methoxybenzamide

Chemical Property:

PSA：58.56000
LogP:2.11940
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:249.13649347
Heavy Atom Count:18
Complexity:274

Purity/Quality:

99% ^*data from raw suppliers

BENZAMIDE, N-(2-HYDROXYCYCLOHEXYL)-4-METHOXY- 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(=O)NC2CCCCC2O

Technology Process of N-(2-hydroxycyclohexyl)-4-methoxybenzamide

There total 4 articles about N-(2-hydroxycyclohexyl)-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19324-69-7,56285-60-0,73446-71-6,142282-84-6
trans-2-bromo-1-methylcyclohexan-1-ol

: 710290-26-9
N-((1R,2S)-2-Hydroxy-cyclohexyl)-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: CCl₄ / 25 °C

2: NaH / tetrahydrofuran / Heating

3: 2.27 M aq. LiOH / tetrahydrofuran / 12 h / 25 °C

With lithium hydroxide; sodium hydride; In tetrahydrofuran; tetrachloromethane;
DOI:10.1021/jo00309a013

Reference yield:

: (4-Methoxy-benzoyl)-carbamic acid (1R,2R)-2-bromo-cyclohexyl ester

: 710290-26-9
N-((1R,2S)-2-Hydroxy-cyclohexyl)-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / Heating

2: 2.27 M aq. LiOH / tetrahydrofuran / 12 h / 25 °C

With lithium hydroxide; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo00309a013

Reference yield:

: 4695-57-2
4-methoxybenzoyl isocyanate

: 710290-26-9
N-((1R,2S)-2-Hydroxy-cyclohexyl)-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: CCl₄ / 25 °C

2: NaH / tetrahydrofuran / Heating

3: 2.27 M aq. LiOH / tetrahydrofuran / 12 h / 25 °C

With lithium hydroxide; sodium hydride; In tetrahydrofuran; tetrachloromethane;
DOI:10.1021/jo00309a013