1-(t-butyl-1,1-dimethylsilyl) (3R,4S)-4-(4-(1,1-di(3,5-di(trifluoromethyl)phenyl)phosphino)-2,5-dimethyl-3-thienyl)tetrahydro-3-furanyl ether

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Chemical Name:1-(t-butyl-1,1-dimethylsilyl) (3R,4S)-4-(4-(1,1-di(3,5-di(trifluoromethyl)phenyl)phosphino)-2,5-dimethyl-3-thienyl)tetrahydro-3-furanyl ether
CAS No.:400711-11-7
Molecular Formula:C₃₂H₃₃F₁₂O₂PSSi
Molecular Weight:768.719
Hs Code.:

Synonyms:1-(t-butyl-1,1-dimethylsilyl) (3R,4S)-4-(4-(1,1-di(3,5-di(trifluoromethyl)phenyl)phosphino)-2,5-dimethyl-3-thienyl)tetrahydro-3-furanyl ether

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Chemical Property of 1-(t-butyl-1,1-dimethylsilyl) (3R,4S)-4-(4-(1,1-di(3,5-di(trifluoromethyl)phenyl)phosphino)-2,5-dimethyl-3-thienyl)tetrahydro-3-furanyl ether

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Technology Process of 1-(t-butyl-1,1-dimethylsilyl) (3R,4S)-4-(4-(1,1-di(3,5-di(trifluoromethyl)phenyl)phosphino)-2,5-dimethyl-3-thienyl)tetrahydro-3-furanyl ether

There total 1 articles about 1-(t-butyl-1,1-dimethylsilyl) (3R,4S)-4-(4-(1,1-di(3,5-di(trifluoromethyl)phenyl)phosphino)-2,5-dimethyl-3-thienyl)tetrahydro-3-furanyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 400711-10-6
(3R,4S)-4-(bromo-2,5-dimethyl-3-thienyl)-tetrahydro-3-furanyl tert-butyldimethylsilyl ether

: 142421-57-6
bis(3,5-di(trifluoromethyl)phenyl)chlorophosphine

: 400711-11-7
1-(t-butyl-1,1-dimethylsilyl) (3R,4S)-4-(4-(1,1-di(3,5-di(trifluoromethyl)phenyl)phosphino)-2,5-dimethyl-3-thienyl)tetrahydro-3-furanyl ether

Guidance literature:: (3R,4S)-4-(bromo-2,5-dimethyl-3-thienyl)-tetrahydro-3-furanyl tert-butyldimethylsilyl ether; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 1.16667h;

bis(3,5-di(trifluoromethyl)phenyl)chlorophosphine; at -78 - 20 ℃;

With water;

Reference yield: 87.0%

: 400711-11-7
1-(t-butyl-1,1-dimethylsilyl) (3R,4S)-4-(4-(1,1-di(3,5-di(trifluoromethyl)phenyl)phosphino)-2,5-dimethyl-3-thienyl)tetrahydro-3-furanyl ether

: (3R,4S)-4-(4-{1,1-Di[3,5-di(trifluoro-methyl)phenyl]phosphino}-2,5-dimethyl-thien-3-yl)-tetrahydro-3-furanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 77.0%

: 400711-11-7
1-(t-butyl-1,1-dimethylsilyl) (3R,4S)-4-(4-(1,1-di(3,5-di(trifluoromethyl)phenyl)phosphino)-2,5-dimethyl-3-thienyl)tetrahydro-3-furanyl ether

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: (3R,4S)-4-(4-{1,1-di[3,5-di(trifluoro-methyl)phenyl]phosphino}-2,5-dimethyl-3-thienyl)tetrahydro-3-furanyl diphenylphosphinite

Guidance literature:: 1-(t-butyl-1,1-dimethylsilyl) (3R,4S)-4-(4-(1,1-di(3,5-di(trifluoromethyl)phenyl)phosphino)-2,5-dimethyl-3-thienyl)tetrahydro-3-furanyl ether; With ethylmagnesium bromide; In tetrahydrofuran; toluene; at 0 ℃; for 1h;

chloro-diphenylphosphine; In tetrahydrofuran; toluene; at 0 - 20 ℃;