Technology Process of tert-butyl 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate
There total 12 articles about tert-butyl 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 48h;
DOI:10.1021/ml500422m
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / toluene; mineral oil / 110 °C
1.2: 48 h / 110 °C
1.3: 16 h / Reflux
2.1: tetrahydrofuran / 16 h / 65 °C
3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere
4.1: sodium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 0.42 h / 23 °C
5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; water / 3 h / 4913.04 Torr
6.1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C
With
hydrogen; dihydrogen peroxide; potassium acetate; sodium hydride; caesium carbonate; sodium hydroxide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran / 16 h / 65 °C
2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere
3: sodium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 0.42 h / 23 °C
4: hydrogen / palladium 10% on activated carbon / ethyl acetate; water / 3 h / 4913.04 Torr
5: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C
With
hydrogen; dihydrogen peroxide; potassium acetate; caesium carbonate; sodium hydroxide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;
