6-bromo-1-(4-fluorobenzyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine

Base Information

Chemical Name:6-bromo-1-(4-fluorobenzyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine
CAS No.:1400287-36-6
Molecular Formula:C₁₈H₁₄BrFN₄
Molecular Weight:385.238
Hs Code.:

Synonyms:6-bromo-1-(4-fluorobenzyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine

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Chemical Property of 6-bromo-1-(4-fluorobenzyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine

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Technology Process of 6-bromo-1-(4-fluorobenzyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine

There total 9 articles about 6-bromo-1-(4-fluorobenzyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.9%

: 1400286-72-7
6-bromo-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine

: 459-46-1
4-Fluorobenzyl bromide

: 1400287-36-6
6-bromo-1-(4-fluorobenzyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: 6-bromo-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine; With sodium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; for 0.333333h;

4-Fluorobenzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 60 ℃; for 3h;

Reference yield:

: 7598-35-8
2-bromo-4-aminopyridine

: 1400287-36-6
6-bromo-1-(4-fluorobenzyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; Iodine monochloride / acetic acid / 3 h / 75 °C

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.75 h / 20 °C / Inert atmosphere

3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 3 h / 50 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.33 h

4.2: 3 h / 60 °C

With potassium tert-butylate; sodium acetate; sodium hexamethyldisilazane; Iodine monochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 39806-89-8
4-ethynyl-1-methyl-1-H-pyrazole

: 1400287-36-6
6-bromo-1-(4-fluorobenzyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.75 h / 60 °C / Inert atmosphere; Sealed vial

2.1: sodium hydroxide / methanol / 6 h / 25 °C

3.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.33 h

3.2: 3 h / 60 °C

With sodium hexamethyldisilazane; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;