(E)-ethyl 2-((2-methylbenzylidene)amino)acetate

Base Information

• Chemical Name: (E)-ethyl 2-((2-methylbenzylidene)amino)acetate
• CAS No.: 1225330-57-3
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 1225330-57-3.mol

Synonyms:(E)-ethyl 2-((2-methylbenzylidene)amino)acetate

Chemical Property of (E)-ethyl 2-((2-methylbenzylidene)amino)acetate

Chemical Property:

Purity/Quality:

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Technology Process of (E)-ethyl 2-((2-methylbenzylidene)amino)acetate

There total 1 articles about (E)-ethyl 2-((2-methylbenzylidene)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

[(benzylidene)amino]acetic acid ethyl ester (133038-44-5) + 2-methylphenyl aldehyde (529-20-4) → (E)-ethyl 2-((2-methylbenzylidene)amino)acetate (1225330-57-3)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 2h;

Reference yield: 81.0%

methyl 2-{[(tert-butoxycarbonyl)oxy](phenyl)methyl}acrylate (956833-12-8) + (E)-ethyl 2-((2-methylbenzylidene)amino)acetate (1225330-57-3) → 1-ethyl 5-methyl (2S,3R)-2-(((E)-2-methylbenzylidene)amino)-4-methylene-3-phenylpentanedioate

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; tetrakis(acetonitrile)copper(I) hexafluorophosphate; (S,Sp)-tBu-Phosferrox; In dichloromethane; at -20 ℃; for 12h; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1039/d1cc02861h

Reference yield: 57.0%

(E)-ethyl 2-((2-methylbenzylidene)amino)acetate (1225330-57-3) + Tropone (539-80-0) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → ethyl 10-oxo-8-phenyl-9-(o-tolyl)-8-azabicyclo[4.3.1]deca-2,4-diene-7-carboxylate

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; at 0 - 25 ℃; for 12h; diastereoselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02662

upstream raw materials:

[(benzylidene)amino]acetic acid ethyl ester

2-methylphenyl aldehyde

Downstream raw materials:

C₁₉H₂₁NO₂

Refernces