(2R,3S)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]-2,3-dihydroxypropanoate

Base Information

• Chemical Name: (2R,3S)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]-2,3-dihydroxypropanoate
• CAS No.: 1144506-94-4
• Molecular Formula: C₂₀H₂₄O₇
• Molecular Weight: 376.406
• Mol file: 1144506-94-4.mol

Synonyms:(2R,3S)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]-2,3-dihydroxypropanoate

Chemical Property of (2R,3S)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]-2,3-dihydroxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (2R,3S)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]-2,3-dihydroxypropanoate

There total 1 articles about (2R,3S)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]-2,3-dihydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(E)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]acrylate (441356-74-7) → (2R,3S)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]-2,3-dihydroxypropanoate (1144506-94-4)

Guidance literature:

With methanesulfonamide; water; hydroquinidein 1,4-phthalazinediyl diether; In tert-butyl alcohol; at 20 ℃; for 73h; optical yield given as %ee; enantioselective reaction; Cooling with ice;

DOI:10.1002/adsc.200800396

Reference yield: 76.0%

(2R,3S)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]-2,3-dihydroxypropanoate (1144506-94-4) → (R)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]-2-hydroxypropanoate (1144506-95-5)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/adsc.200800396

upstream raw materials:

(E)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]acrylate

Downstream raw materials:

(R)-ethyl 3-[2-(benzyloxy)-4-(methoxymethoxy)phenyl]-2-hydroxypropanoate