N-(9-{(3R,4R,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Base Information

Chemical Name:N-(9-{(3R,4R,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide
CAS No.:205382-60-1
Molecular Formula:C₄₁H₅₁N₅O₇Si
Molecular Weight:753.971
Hs Code.:

N-(9-{(3R,4R,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Synonyms:N-(9-{(3R,4R,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

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Chemical Property of N-(9-{(3R,4R,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

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Technology Process of N-(9-{(3R,4R,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

There total 8 articles about N-(9-{(3R,4R,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 205382-59-8
N-{9-[(3R,4R,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide

: 14470-28-1
mono-4-methoxytrityl chloride

: 205382-60-1
N-(9-{(3R,4R,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: In pyridine; Ambient temperature;
DOI:10.1021/jo9718511

Reference yield:

: 89872-97-9
(4aR,7S,8R,8aR)-8-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

: 205382-60-1
N-(9-{(3R,4R,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / pyridine / CH₂Cl₂ / -5 °C

2: 70 percent / dimethylsulfoxide

3: 96 percent / aq. NaOH / dioxane

4: 70 percent / imidazole / dimethylformamide

5: 100 percent / pyridine

6: 80 percent / CF₃COOH / CH₂Cl₂

7: 75 percent / pyridine

With pyridine; 1H-imidazole; sodium hydroxide; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1080/07328319808004713

Reference yield:

: 205382-57-6
1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(guanin-9-yl)-D-mannitol

: 205382-60-1
N-(9-{(3R,4R,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / imidazole / dimethylformamide

2: 100 percent / pyridine

3: 80 percent / CF₃COOH / CH₂Cl₂

4: 75 percent / pyridine

With pyridine; 1H-imidazole; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/07328319808004713