(2E)-2-(benzoylamino)-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-propenoic acid

Base Information

• Chemical Name: (2E)-2-(benzoylamino)-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-propenoic acid
• CAS No.: 220467-58-3
• Molecular Formula: C₁₅H₁₅N₃O₃
• Molecular Weight: 285.302
• Mol file: 220467-58-3.mol

Synonyms:(2E)-2-(benzoylamino)-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-propenoic acid

Chemical Property of (2E)-2-(benzoylamino)-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-propenoic acid

Chemical Property:

Purity/Quality:

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Technology Process of (2E)-2-(benzoylamino)-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-propenoic acid

There total 1 articles about (2E)-2-(benzoylamino)-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(5-acetyl-6-methyl-2-oxo-2H-pyran-3-yl)-benzamide (93945-84-7) → (2E)-2-(benzoylamino)-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-propenoic acid (220467-58-3)

Guidance literature:

With hydrazine; In pyridine; ethanol; at 20 ℃; for 1.16667h;

DOI:10.1016/S0040-4020(98)01032-1

Reference yield:

(2E)-2-(benzoylamino)-3-(3,5-dimethyl-1H-pyrazol-4-yl)-2-propenoic acid (220467-58-3) → N-benzoyl-3-(3,5-dimethyl-1H-pyrazol-4-yl)alanine (1137464-53-9)

Guidance literature:

With acetylacetonatodicarbonylrhodium(l); carbon monoxide; tetrabutylammomium bromide; hydrogen; In isopropyl alcohol; at 80 ℃; under 75007.5 Torr;

DOI:10.1002/anie.200803773

upstream raw materials:

N-(5-acetyl-6-methyl-2-oxo-2H-pyran-3-yl)-benzamide

Downstream raw materials:

N-benzoyl-3-(3,5-dimethyl-1H-pyrazol-4-yl)alanine