3-Amino-4-N-desmethyl-3-desoxy-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

Base Information

• Chemical Name: 3-Amino-4-N-desmethyl-3-desoxy-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂
• CAS No.: 97119-43-2
• Molecular Formula: C₄₁H₅₁N₅O₁₃S₅
• Molecular Weight: 982.212

Synonyms:3-Amino-4-N-desmethyl-3-desoxy-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

Chemical Property of 3-Amino-4-N-desmethyl-3-desoxy-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

Chemical Property:

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Technology Process of 3-Amino-4-N-desmethyl-3-desoxy-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

There total 6 articles about 3-Amino-4-N-desmethyl-3-desoxy-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-Azido-4-N-desmethyl-3-desoxy-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG2 → 3-Amino-4-N-desmethyl-3-desoxy-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG2 (97119-43-2)

Guidance literature:

With hydrogen sulfide; In pyridine; triethylamine; for 1h; Ambient temperature;

DOI:10.1002/jlac.198519850511

Reference yield:

Sisamin (47086-84-0,68297-05-2) → 3-Amino-4-N-desmethyl-3-desoxy-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG2 (97119-43-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / K₂CO₃ / H₂O; dioxane / 1) from 0 deg C to room temp., 2) 2 h, 20 deg C

2: 84 percent / pyridine; CH₂Cl₂ / 3 h / Ambient temperature

3: 32 percent / NaH / dimethylformamide / 0.5 h / 0 °C

4: 80 percent / NaN₃ / dimethylformamide / 0.17 h / 60 °C

5: 76 percent / H₂S / pyridine; triethylamine / 1 h / Ambient temperature

With sodium azide; hydrogen sulfide; sodium hydride; potassium carbonate; In 1,4-dioxane; pyridine; dichloromethane; water; triethylamine; N,N-dimethyl-formamide;

DOI:10.1002/jlac.198519850511

Reference yield:

1,2',3,6'-Tetrakis-N-(p-tolylsulfonyl)sisamin (97119-33-0) → 3-Amino-4-N-desmethyl-3-desoxy-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG2 (97119-43-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / pyridine; CH₂Cl₂ / 3 h / Ambient temperature

2: 32 percent / NaH / dimethylformamide / 0.5 h / 0 °C

3: 80 percent / NaN₃ / dimethylformamide / 0.17 h / 60 °C

4: 76 percent / H₂S / pyridine; triethylamine / 1 h / Ambient temperature

With sodium azide; hydrogen sulfide; sodium hydride; In pyridine; dichloromethane; triethylamine; N,N-dimethyl-formamide;

DOI:10.1002/jlac.198519850511

upstream raw materials:

Sisamin

1,2',3,6'-Tetrakis-N-(p-tolylsulfonyl)sisamin

1-Desamino-6-desoxy-5-O-(methylsulfonyl)-2',3,6'-tris-N-(p-tolylsulfonyl)-1,6-<(p-tolylsulfonyl)epimino>sisamin

5,6-Bis-O-(methylsulfonyl)-1,2',3,6'-tetrakis-N-(p-tolylsulfonyl)sisamin

Downstream raw materials:

3-Amino-4-N-desmethyl-3-desoxyfortimicin KG₂

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