6-N-benzoyl-9-(3,5-O-bis-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl)adenine

Base Information

• Chemical Name: 6-N-benzoyl-9-(3,5-O-bis-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl)adenine
• CAS No.: 903882-59-7
• Molecular Formula: C₅₉H₅₃N₅O₉
• Molecular Weight: 976.098
• Mol file: 903882-59-7.mol

Synonyms:6-N-benzoyl-9-(3,5-O-bis-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl)adenine

Chemical Property of 6-N-benzoyl-9-(3,5-O-bis-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl)adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-N-benzoyl-9-(3,5-O-bis-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl)adenine

There total 2 articles about 6-N-benzoyl-9-(3,5-O-bis-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N6-benzoyl-9-β-D-arabinofuranosyladenine (79896-97-2) → 6-N-benzoyl-9-(2,5-O-bis-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl)adenine + 6-N-benzoyl-9-(3,5-O-bis-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl)adenine (903882-59-7)

Guidance literature:

With pyridine; triethylamine; at 20 ℃;

DOI:10.1021/jm050401v

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + N6-benzoyl-9-β-D-arabinofuranosyladenine (79896-97-2) → 6-N-benzoyl-9-(3,5-O-bis-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl)adenine (903882-59-7)

Guidance literature:

N6-benzoyl-9-β-D-arabinofuranosyladenine; With pyridine; at 20 ℃;

4,4'-dimethoxytrityl chloride; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃;

DOI:10.1081/NCN-120022734

Reference yield:

bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate (35717-98-7) + 6-N-benzoyl-9-(3,5-O-bis-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl)adenine (903882-59-7) → {(2R,3S,4R,5R)-2-(6-Benzoylamino-purin-9-yl)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yloxymethyl}-phosphonic acid diisopropyl ester

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1081/NCN-120022734 DOI:10.1021/jm050401v

upstream raw materials:

4,4'-dimethoxytrityl chloride

N6-benzoyl-9-β-D-arabinofuranosyladenine

Downstream raw materials:

diisopropyl [1-(6-N-benzoyladenin-9-yl)-β-D-arabinofuranos-2-O-yl]methylphosphonate

diisopropyl [3-O-benzoyl-1-(6-N-benzoyladenin-9-yl)-5-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranos-2-O-yl]methylphosphonate