Bicyclo[4.1.0]hept-3-en-2-one, 5-hydroxy-4,6-dimethyl-5-[(1E)-3-oxo-1-butenyl]-, (1R,5R,6S)-rel- (9CI)

Base Information

Chemical Name:Bicyclo[4.1.0]hept-3-en-2-one, 5-hydroxy-4,6-dimethyl-5-[(1E)-3-oxo-1-butenyl]-, (1R,5R,6S)-rel- (9CI)
CAS No.:709042-92-2
Molecular Formula:C₁₃H₁₆O₃
Molecular Weight:220.268
Hs Code.:
Mol file:709042-92-2.mol

Synonyms:Bicyclo[4.1.0]hept-3-en-2-one,5-hydroxy-4,6-dimethyl-5-[(1E)-3-oxo-1-butenyl]-, (1R,5R,6S)-rel- (9CI)

Suppliers and Price of Bicyclo[4.1.0]hept-3-en-2-one, 5-hydroxy-4,6-dimethyl-5-[(1E)-3-oxo-1-butenyl]-, (1R,5R,6S)-rel- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Bicyclo[4.1.0]hept-3-en-2-one, 5-hydroxy-4,6-dimethyl-5-[(1E)-3-oxo-1-butenyl]-, (1R,5R,6S)-rel- (9CI)

Chemical Property:

PSA：54.37000
LogP:1.41790

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Bicyclo[4.1.0]hept-3-en-2-one, 5-hydroxy-4,6-dimethyl-5-[(1E)-3-oxo-1-butenyl]-, (1R,5R,6S)-rel- (9CI)

There total 3 articles about Bicyclo[4.1.0]hept-3-en-2-one, 5-hydroxy-4,6-dimethyl-5-[(1E)-3-oxo-1-butenyl]-, (1R,5R,6S)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,5S,6R)-5-Hydroxy-5-((E)-3-hydroxy-but-1-enyl)-4,6-dimethyl-bicyclo[4.1.0]hept-3-en-2-one

: 709042-92-2
(1'RS,5'RS,6'SR)-(+/-)-(3E)-4-(1'-hydroxy-5',6'-methano-2',6'-dimethyl-4'-oxo-2'-cyclohexen-1'-yl)-3-buten-2-one

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2003.10.048

Reference yield:

: 113282-72-7
4,6-dimethyl-5H-spiro-[bicyclo[4.1.0]hept-3-ene-2,2'-[1,3]dioxolane]-5-one

: 709042-92-2
(1'RS,5'RS,6'SR)-(+/-)-(3E)-4-(1'-hydroxy-5',6'-methano-2',6'-dimethyl-4'-oxo-2'-cyclohexen-1'-yl)-3-buten-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 28 percent / tetrahydrofuran; hexane / 5 h / -78 - 20 °C

2.1: sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran / 4 h / 20 °C

2.2: 33 mg / AcOH / tetrahydrofuran; H₂O / 17 h / 20 °C

3.1: 30 mg / MnO₂ / CH₂Cl₂ / 2 h / 20 °C

With manganese(IV) oxide; n-butyllithium; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.bmc.2003.10.048

Reference yield:

: C₂₁H₃₄O₄Si

: 709042-92-2
(1'RS,5'RS,6'SR)-(+/-)-(3E)-4-(1'-hydroxy-5',6'-methano-2',6'-dimethyl-4'-oxo-2'-cyclohexen-1'-yl)-3-buten-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran / 4 h / 20 °C

1.2: 33 mg / AcOH / tetrahydrofuran; H₂O / 17 h / 20 °C

2.1: 30 mg / MnO₂ / CH₂Cl₂ / 2 h / 20 °C

With manganese(IV) oxide; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2003.10.048