(2S)-5-[({1-[(cyclohexylcarbonyl)oxy]-2-methylpropoxy}carbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid

Base Information

Chemical Name:(2S)-5-[({1-[(cyclohexylcarbonyl)oxy]-2-methylpropoxy}carbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid
CAS No.:1224847-56-6
Molecular Formula:C₂₉H₃₉N₃O₆
Molecular Weight:525.645
Hs Code.:

Synonyms:(2S)-5-[({1-[(cyclohexylcarbonyl)oxy]-2-methylpropoxy}carbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid

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Chemical Property of (2S)-5-[({1-[(cyclohexylcarbonyl)oxy]-2-methylpropoxy}carbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid

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Technology Process of (2S)-5-[({1-[(cyclohexylcarbonyl)oxy]-2-methylpropoxy}carbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid

There total 12 articles about (2S)-5-[({1-[(cyclohexylcarbonyl)oxy]-2-methylpropoxy}carbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1224849-40-4
2-methyl-1-{[(4-nitrophenoxy)carbonyl]oxy}propyl cyclohexanecarboxylate

: 1224846-59-6
(2S)-5-amino-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid

: 1224847-56-6
(2S)-5-[({1-[(cyclohexylcarbonyl)oxy]-2-methylpropoxy}carbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 553-03-7
3,4-dihydro-2(1H)-quinolone

: 1224847-56-6
(2S)-5-[({1-[(cyclohexylcarbonyl)oxy]-2-methylpropoxy}carbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Cooling with ice

1.2: 1 h / -30 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

3.1: manganese(IV) oxide / chloroform / 15 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

4.2: 1 h / -78 °C

4.3: 1 h / 20 °C / Cooling with ice

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 60 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / chloroform / 15 h / 20 °C

8.1: hydrogen / palladium 10% on activated carbon / methanol / 10 h / 60 °C

9.1: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C

10.1: N,N-dimethyl-formamide / 48 h / 20 °C

With hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; potassium tert-butylate; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; lithium hexamethyldisilazane; dmap; palladium 10% on activated carbon; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 1224847-65-7
ethyl 4,5-dihydroimidazo[1,5-a]quinoline-3-carboxylate

: 1224847-56-6
(2S)-5-[({1-[(cyclohexylcarbonyl)oxy]-2-methylpropoxy}carbonyl)amino]-2-(4,5-dihydroimidazo[1,5-a]quinolin-3-ylmethyl)pentanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

2.1: manganese(IV) oxide / chloroform / 15 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1 h / -78 °C

3.3: 1 h / 20 °C / Cooling with ice

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 60 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / chloroform / 15 h / 20 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 10 h / 60 °C

8.1: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C

9.1: N,N-dimethyl-formamide / 48 h / 20 °C

With hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; lithium hexamethyldisilazane; dmap; palladium 10% on activated carbon; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide;