tert-butyl (3R)-6-cyclohexyl-3-(3-{[(phenylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate

Base Information

Chemical Name:tert-butyl (3R)-6-cyclohexyl-3-(3-{[(phenylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate
CAS No.:438630-60-5
Molecular Formula:C₂₅H₃₇N₃O₅S
Molecular Weight:491.652
Hs Code.:

Synonyms:tert-butyl (3R)-6-cyclohexyl-3-(3-{[(phenylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate

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Chemical Property of tert-butyl (3R)-6-cyclohexyl-3-(3-{[(phenylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate

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Technology Process of tert-butyl (3R)-6-cyclohexyl-3-(3-{[(phenylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate

There total 3 articles about tert-butyl (3R)-6-cyclohexyl-3-(3-{[(phenylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 438630-57-0
tert-butyl (3R)-6-cyclohexyl-3-(3-{[methyl(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate

: 438630-60-5
tert-butyl (3R)-6-cyclohexyl-3-(3-{[(phenylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate

Guidance literature:

Reference yield:

: 348622-98-0
ethyl 5-{(1R)-1-[2-(tert-butoxy)-2-oxoethyl]-4-cyclohexylbutyl)-1,2,4-oxadiazole-3-carboxylate

: 438630-60-5
tert-butyl (3R)-6-cyclohexyl-3-(3-{[(phenylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄

2: 94 percent / NH₃ / tetrahydrofuran / 18 h / 50 °C

3: 85 percent / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; ammonia; In tetrahydrofuran;
DOI:10.1021/jm061010z

Reference yield:

: 348623-96-1
tert-butyl (3R)-6-cyclohexyl-3-[3-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1,2,4-oxadiazol-5-yl]hexanoate

: 438630-60-5
tert-butyl (3R)-6-cyclohexyl-3-(3-{[(phenylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / NH₃ / tetrahydrofuran / 18 h / 50 °C

2: 85 percent / tetrahydrofuran / 20 °C

With ammonia; In tetrahydrofuran;
DOI:10.1021/jm061010z