ethyl 2-((3R)-1-(2-hydroxy-2-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl) piperidin-3-yl)acetate

Base Information

Chemical Name:ethyl 2-((3R)-1-(2-hydroxy-2-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl) piperidin-3-yl)acetate
CAS No.:1265324-38-6
Molecular Formula:C₂₈H₂₈F₃N₅O₅
Molecular Weight:571.556
Hs Code.:

Synonyms:ethyl 2-((3R)-1-(2-hydroxy-2-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl) piperidin-3-yl)acetate

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Chemical Property of ethyl 2-((3R)-1-(2-hydroxy-2-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl) piperidin-3-yl)acetate

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Technology Process of ethyl 2-((3R)-1-(2-hydroxy-2-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl) piperidin-3-yl)acetate

There total 5 articles about ethyl 2-((3R)-1-(2-hydroxy-2-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl) piperidin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₀H₄ClF₃N₂O₂

: 1265750-14-8
ethyl 2-((3R)-1-(2-hydroxy-2-(4-((Z)-N'-hydroxycarbamimidoyl)-phenyl)ethyl)piperidin-3-yl)acetate

: 1265324-38-6
ethyl 2-((3R)-1-(2-hydroxy-2-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl) piperidin-3-yl)acetate

Guidance literature:: In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 69716-28-5
2-pyridylhydroxyiminomethyl chloride

: 1265324-38-6
ethyl 2-((3R)-1-(2-hydroxy-2-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl) piperidin-3-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: indium(III) chloride / ethyl acetate / 0.5 h / Inert atmosphere

1.2: 14 h

2.1: water; lithium hydroxide monohydrate / methanol / 1 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / Inert atmosphere

4.1: dichloromethane / 72 h / 20 °C

With indium(III) chloride; oxalyl dichloride; lithium hydroxide monohydrate; water; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 1193-96-0
(E)-pyridin-2-aldoxime

: 1265324-38-6
ethyl 2-((3R)-1-(2-hydroxy-2-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl) piperidin-3-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 - 60 °C

2.1: indium(III) chloride / ethyl acetate / 0.5 h / Inert atmosphere

2.2: 14 h

3.1: water; lithium hydroxide monohydrate / methanol / 1 h / 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / Inert atmosphere

5.1: dichloromethane / 72 h / 20 °C

With indium(III) chloride; N-chloro-succinimide; oxalyl dichloride; lithium hydroxide monohydrate; water; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;