Boc((S)PheΨ[CON(Pht)](R)Ala)₂OH

Base Information

• Chemical Name: Boc((S)PheΨ[CON(Pht)](R)Ala)₂OH
• CAS No.: 1091604-13-5
• Molecular Formula: C₄₅H₄₄N₆O₁₁
• Molecular Weight: 844.878
• Mol file: 1091604-13-5.mol

Synonyms:Boc((S)PheΨ[CON(Pht)](R)Ala)₂OH

Chemical Property of Boc((S)PheΨ[CON(Pht)](R)Ala)₂OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc((S)PheΨ[CON(Pht)](R)Ala)₂OH

There total 6 articles about Boc((S)PheΨ[CON(Pht)](R)Ala)₂OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Boc(Pheψ[CON(Pht)](R)Ala)2OBn (1091603-93-8) → Boc((S)PheΨ[CON(Pht)](R)Ala)2OH (1091604-13-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.tet.2008.08.087

Reference yield:

BocPheψ[CON(Pht)](R)AlaOBn (1091604-06-6) → Boc((S)PheΨ[CON(Pht)](R)Ala)2OH (1091604-13-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

2: sodium hydrogencarbonate / dichloromethane / 10 - 20 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In ethanol; dichloromethane; ethyl acetate;

DOI:10.1016/j.tet.2012.02.070

Reference yield:

Boc-Phe-NH-NPht (1171816-73-1) → Boc((S)PheΨ[CON(Pht)](R)Ala)2OH (1091604-13-5)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 1 h / 20 °C

3: sodium hydrogencarbonate / dichloromethane / 10 - 20 °C

4: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 1: Mitsunobu reaction;

DOI:10.1016/j.tet.2012.02.070

upstream raw materials:

Boc(Pheψ[CON(Pht)](R)Ala)2OBn

BocPheψ[CON(Pht)](R)AlaOBn

BocPheψ[CON(Pht)](R)AlaOH

Boc-Phe-NH-NPht