3-{1-[4-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)butyl]-1H-indol-3-ylmethylene}-1,3-dihydro-indol-2-one

Base Information

Chemical Name:3-{1-[4-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)butyl]-1H-indol-3-ylmethylene}-1,3-dihydro-indol-2-one
CAS No.:1529772-92-6
Molecular Formula:C₃₆H₂₈N₂O₅
Molecular Weight:568.629
Hs Code.:

Synonyms:3-{1-[4-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)butyl]-1H-indol-3-ylmethylene}-1,3-dihydro-indol-2-one

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Chemical Property of 3-{1-[4-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)butyl]-1H-indol-3-ylmethylene}-1,3-dihydro-indol-2-one

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Technology Process of 3-{1-[4-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)butyl]-1H-indol-3-ylmethylene}-1,3-dihydro-indol-2-one

There total 3 articles about 3-{1-[4-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)butyl]-1H-indol-3-ylmethylene}-1,3-dihydro-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 59-48-3
2-oxoindole

: 1529772-97-1
C₂₈H₂₃NO₅

: 1529772-92-6
3-{1-[4-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)butyl]-1H-indol-3-ylmethylene}-1,3-dihydro-indol-2-one

Guidance literature:: at 160 - 180 ℃;
DOI:10.1016/j.bmcl.2013.11.080

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 1529772-92-6
3-{1-[4-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)butyl]-1H-indol-3-ylmethylene}-1,3-dihydro-indol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide

2: potassium carbonate / acetone / Reflux; Inert atmosphere

3: 160 - 180 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetone; 3: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2013.11.080

Reference yield:

: 1-(4-bromobutyl)-1H-indole-3-carbaldehyde

: 1529772-92-6
3-{1-[4-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)butyl]-1H-indol-3-ylmethylene}-1,3-dihydro-indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux; Inert atmosphere

2: 160 - 180 °C

With potassium carbonate; In acetone; 2: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2013.11.080