N-[1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]-N-[1-(2,4-dimethoxyphenyl)ethyl]benzamide

Base Information

• Chemical Name: N-[1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]-N-[1-(2,4-dimethoxyphenyl)ethyl]benzamide
• CAS No.: 1598420-53-1
• Molecular Formula: C₂₉H₄₀N₂O₄
• Molecular Weight: 480.648
• Mol file: 1598420-53-1.mol

Synonyms:N-[1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]-N-[1-(2,4-dimethoxyphenyl)ethyl]benzamide

Chemical Property of N-[1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]-N-[1-(2,4-dimethoxyphenyl)ethyl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]-N-[1-(2,4-dimethoxyphenyl)ethyl]benzamide

There total 4 articles about N-[1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]-N-[1-(2,4-dimethoxyphenyl)ethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyclohexyl isocyanide (931-53-3) + (S)-α-(2,4-dimethoxyphenyl)ethylamine (1212264-50-0) + benzoic acid (65-85-0,8013-63-6) + isovaleraldehyde (590-86-3) → N-[1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]-N-[1-(2,4-dimethoxyphenyl)ethyl]benzamide (1598420-53-1) + N-[1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]-N-[1-(2,4-dimethoxyphenyl)ethyl]benzamide (1598420-67-7)

Guidance literature:

(S)-α-(2,4-dimethoxyphenyl)ethylamine; isovaleraldehyde; In ethanol; at 20 ℃; for 0.5h;

Cyclohexyl isocyanide; benzoic acid; In ethanol; at 0 - 20 ℃; for 24h; Solvent; Temperature; Overall yield = 77 %;

DOI:10.1016/j.tetasy.2014.01.016

Reference yield:

2',4'-dimethoxyacetophenone (829-20-9) → N-[1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]-N-[1-(2,4-dimethoxyphenyl)ethyl]benzamide (1598420-53-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonium carbonate / water / 2 h / 135 °C / Reflux

1.2: Reflux

2.1: sodium hydroxide / water / 4 h / Reflux

3.1: Novozym 435 / toluene / 48 h / 25 °C / Enzymatic reaction

4.1: ethanol / 0.5 h / 20 °C

4.2: 24 h / 0 - 20 °C

With ammonium carbonate; sodium hydroxide; In ethanol; water; toluene; 4.1: |Ugi Condensation / 4.2: |Ugi Condensation;

DOI:10.1016/j.tetasy.2014.01.016

Reference yield:

C16H17NO3 → N-[1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]-N-[1-(2,4-dimethoxyphenyl)ethyl]benzamide (1598420-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 4 h / Reflux

2.1: Novozym 435 / toluene / 48 h / 25 °C / Enzymatic reaction

3.1: ethanol / 0.5 h / 20 °C

3.2: 24 h / 0 - 20 °C

With sodium hydroxide; In ethanol; water; toluene; 3.1: |Ugi Condensation / 3.2: |Ugi Condensation;

DOI:10.1016/j.tetasy.2014.01.016

upstream raw materials:

2',4'-dimethoxyacetophenone

α-(2,4-dimethoxyphenyl)ethyl amine

Cyclohexyl isocyanide

(S)-α-(2,4-dimethoxyphenyl)ethylamine

Downstream raw materials:

N-[1-(cyclohexylamino)-4-methyl-1-oxopentan-2-yl]benzamide