tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate
CAS No.:1432755-79-7
Molecular Formula:C₃₂H₃₈N₆O₇S₂
Molecular Weight:682.822
Hs Code.:

tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Synonyms:tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

There total 5 articles about tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1427750-91-1
tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfonylpiperidine-1-carboxylate

: 1232423-76-5
tert-butyl-N-[5-bromo-3-[5-(3-methyl-2-thienyl)-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-N-tert-butoxycarbonyl-carbamate

: 1432755-79-7
tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; sodium carbonate; at 65 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 887590-15-0
tert-butyl 3-((4-bromophenyl)sulfonyl)piperidine-1-carboxylate

: 1432755-79-7
tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

2: sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1.5 h / 65 °C / Inert atmosphere

With (bis(tricyclohexyl)phosphine)palladium(II) dichloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium acetate; sodium carbonate; In 1,4-dioxane;

Reference yield:

: 85275-45-2
N-tert-butoxycarbonyl-3-piperidinol

: 1432755-79-7
tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / 3 h / 20 °C

4: potassium acetate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

5: sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1.5 h / 65 °C / Inert atmosphere

With (bis(tricyclohexyl)phosphine)palladium(II) dichloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium acetate; sodium carbonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;