1-Pyrrolidinepropanoic acid, 2-thioxo-, ethyl ester

Base Information

Chemical Name:1-Pyrrolidinepropanoic acid, 2-thioxo-, ethyl ester
CAS No.:74991-93-8
Molecular Formula:C₉H₁₅NO₂S
Molecular Weight:201.29
Hs Code.:
Mol file:74991-93-8.mol

Synonyms:1-Pyrrolidinepropanoic acid, 2-thioxo-, ethyl ester

Suppliers and Price of 1-Pyrrolidinepropanoic acid, 2-thioxo-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 1-Pyrrolidinepropanoic acid, 2-thioxo-, ethyl ester

Chemical Property:

PSA：61.63000
LogP:1.30070

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinepropanoic acid, 2-thioxo-, ethyl ester

There total 2 articles about 1-Pyrrolidinepropanoic acid, 2-thioxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2295-35-4
pyrrolidin-2-thione

: 140-88-5,9003-32-1
ethyl acrylate

: 74991-93-8
ethyl 3-(2-thioxopyrrolidin-1-yl)propanoate

Guidance literature:: sodium hydroxide; In tetrahydrofuran; at 55 ℃; for 3.5h;
DOI:10.1016/S0040-4039(00)74580-1

Reference yield:

: 61930-87-8
1-(2-oxopyrrolidine)propanoic acid ethyl ester

: 74991-93-8
ethyl 3-(2-thioxopyrrolidin-1-yl)propanoate

Guidance literature:: With diphosphorus pentasulfide;
DOI:10.1039/b413379j

Reference yield:

: 74991-93-8
ethyl 3-(2-thioxopyrrolidin-1-yl)propanoate

: (8RS,8aSR)-8-[(4-methylphenyl)sulfonyl]octahydroindolizine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 17 h / 0 °C

2: Et₃N / CH₂Cl₂ / 72 h / 20 °C

3: 94 percent / LiAlH₄ / tetrahydrofuran / 15 h / 20 °C

4: 80 percent / PPh₃; imidazole; I₂ / acetonitrile / 2 h / Heating

5: 7 percent / NaBH₄ / methanol / 24 h

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; iodine; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1039/b413379j