N-[(S)-1-phenylethyl]-N-[(S)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine

Base Information

Chemical Name:N-[(S)-1-phenylethyl]-N-[(S)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine
CAS No.:1392441-63-2
Molecular Formula:C₂₀H₂₉NO₃
Molecular Weight:331.455
Hs Code.:

Synonyms:N-[(S)-1-phenylethyl]-N-[(S)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine

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Chemical Property of N-[(S)-1-phenylethyl]-N-[(S)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine

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Technology Process of N-[(S)-1-phenylethyl]-N-[(S)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine

There total 4 articles about N-[(S)-1-phenylethyl]-N-[(S)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₇NO₃

: 1392441-63-2
N-[(S)-1-phenylethyl]-N-[(S)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine

: 1392441-64-3
N-[(S)-1-phenylethyl]-N-[(R)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine

Guidance literature:: With methanol; sodium tetrahydroborate; at 0 ℃; for 1h; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tetasy.2012.06.017

Reference yield:

: 93563-64-5
C₁₃H₁₉NO₄

: 1392441-63-2
N-[(S)-1-phenylethyl]-N-[(S)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine

: 1392441-64-3
N-[(S)-1-phenylethyl]-N-[(R)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; magnesium / tetrahydrofuran / 0.67 h / Inert atmosphere; Reflux

1.2: 3.08 h / Inert atmosphere; Reflux

2.1: titanium tetrachloride; triethylamine / toluene / 12 h / 0 °C / Reflux

3.1: methanol; sodium tetrahydroborate / 1 h / 0 °C

With methanol; sodium tetrahydroborate; iodine; titanium tetrachloride; magnesium; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1016/j.tetasy.2012.06.017

Reference yield:

: 93563-57-6
C₉H₁₂O₅

: 1392441-63-2
N-[(S)-1-phenylethyl]-N-[(S)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine

: 1392441-64-3
N-[(S)-1-phenylethyl]-N-[(R)-1-(2,4,10-trioxaadamant-3-yl)-3-methylbutyl]amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium chloride / tetrahydrofuran / 12.08 h / 25 °C

2.1: iodine; magnesium / tetrahydrofuran / 0.67 h / Inert atmosphere; Reflux

2.2: 3.08 h / Inert atmosphere; Reflux

3.1: titanium tetrachloride; triethylamine / toluene / 12 h / 0 °C / Reflux

4.1: methanol; sodium tetrahydroborate / 1 h / 0 °C

With methanol; sodium tetrahydroborate; iodine; titanium tetrachloride; magnesium; triethylamine; magnesium chloride; In tetrahydrofuran; toluene;
DOI:10.1016/j.tetasy.2012.06.017