(S)-N-((1-(benzyloxycarbonyl)pyrrolidin-2-yl)methyl)-N,N-dimethyloctan-1-aminium bromide

Base Information

Chemical Name:(S)-N-((1-(benzyloxycarbonyl)pyrrolidin-2-yl)methyl)-N,N-dimethyloctan-1-aminium bromide
CAS No.:1316160-39-0
Molecular Formula:Br*C₂₃H₃₉N₂O₂
Molecular Weight:455.479
Hs Code.:

Synonyms:(S)-N-((1-(benzyloxycarbonyl)pyrrolidin-2-yl)methyl)-N,N-dimethyloctan-1-aminium bromide

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Chemical Property of (S)-N-((1-(benzyloxycarbonyl)pyrrolidin-2-yl)methyl)-N,N-dimethyloctan-1-aminium bromide

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Technology Process of (S)-N-((1-(benzyloxycarbonyl)pyrrolidin-2-yl)methyl)-N,N-dimethyloctan-1-aminium bromide

There total 6 articles about (S)-N-((1-(benzyloxycarbonyl)pyrrolidin-2-yl)methyl)-N,N-dimethyloctan-1-aminium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 111-83-1
1-bromo-octane

: 1316160-31-2
(S)-benzyl 2-((dimethylamino) methyl)pyrrolidine-1-carboxylate

: 1316160-39-0
(S)-N-((1-(benzyloxycarbonyl)pyrrolidin-2-yl)methyl)-N,N-dimethyloctan-1-aminium bromide

Guidance literature:: In acetonitrile; at 85 ℃; Inert atmosphere;
DOI:10.1007/s10562-011-0649-4

Reference yield:

: 6216-63-3
N-Cbz-Prolinol

: 1316160-39-0
(S)-N-((1-(benzyloxycarbonyl)pyrrolidin-2-yl)methyl)-N,N-dimethyloctan-1-aminium bromide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

2: lithium bromide monohydrate / tetrahydrofuran / 16 h / Inert atmosphere; Reflux

3: methanol; water / 18 h / 55 °C

4: acetonitrile / 85 °C / Inert atmosphere

With lithium bromide monohydrate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1007/s10562-011-0649-4

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1316160-39-0
(S)-N-((1-(benzyloxycarbonyl)pyrrolidin-2-yl)methyl)-N,N-dimethyloctan-1-aminium bromide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: triethylamine / dichloromethane / 18 h / 0 - 20 °C

3: lithium bromide monohydrate / tetrahydrofuran / 16 h / Inert atmosphere; Reflux

4: methanol; water / 18 h / 55 °C

5: acetonitrile / 85 °C / Inert atmosphere

With lithium bromide monohydrate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1007/s10562-011-0649-4