Technology Process of 6-((2S,5R,6S)-5-((2S,5S,6R)-5-benzyloxy-6-methyl-tetrahydropyranyloxy)-6-methyltetrahydro-2-pyranyl)-1,4-dihydro-1,4-epoxy-5,9,10-trimethoxyanthracene
There total 9 articles about 6-((2S,5R,6S)-5-((2S,5S,6R)-5-benzyloxy-6-methyl-tetrahydropyranyloxy)-6-methyltetrahydro-2-pyranyl)-1,4-dihydro-1,4-epoxy-5,9,10-trimethoxyanthracene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran;
at -78 - 23 ℃;
DOI:10.1021/ol061007+
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 59 percent / Cp2HfCl2; AgClO4; 4 Angstroem molecular sieves / CH2Cl2 / 4 h / -78 - 23 °C
2: 96 percent / NaH / dimethylformamide / 4 h / 0 - 23 °C
3: 92 percent / K2CO3 / methanol / 18 h / 23 °C
4: 78 percent / InCl3 / CH2Cl2 / 1 h
5: 90 percent / H2 / Pd/C / ethyl acetate
6: 100 percent / K2CO3 / methanol / 18 h
7: 83 percent / NaH / dimethylformamide / 18 h / 23 °C
8: 85 percent / n-BuLi / tetrahydrofuran / -78 - 23 °C
With
indium(III) chloride; n-butyllithium; bis(cyclopentadienyl)hafnium dichloride; 4 A molecular sieve; hydrogen; silver perchlorate; sodium hydride; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol061007+
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 78 percent / InCl3 / CH2Cl2 / 1 h
2: 90 percent / H2 / Pd/C / ethyl acetate
3: 100 percent / K2CO3 / methanol / 18 h
4: 83 percent / NaH / dimethylformamide / 18 h / 23 °C
5: 85 percent / n-BuLi / tetrahydrofuran / -78 - 23 °C
With
indium(III) chloride; n-butyllithium; hydrogen; sodium hydride; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol061007+
