8-hydroxymethyl-des-AB-cholest-8-ene p-nitrobenzoate

Base Information

Chemical Name:8-hydroxymethyl-des-AB-cholest-8-ene p-nitrobenzoate
CAS No.:3752-57-6
Molecular Formula:C₂₆H₃₇NO₄
Molecular Weight:427.584
Hs Code.:

Synonyms:8-hydroxymethyl-des-AB-cholest-8-ene p-nitrobenzoate

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Chemical Property of 8-hydroxymethyl-des-AB-cholest-8-ene p-nitrobenzoate

Chemical Property:

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Technology Process of 8-hydroxymethyl-des-AB-cholest-8-ene p-nitrobenzoate

There total 21 articles about 8-hydroxymethyl-des-AB-cholest-8-ene p-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101039-52-5,101221-78-7
C₁₉H₃₂O₂

: 3752-57-6
8-hydroxymethyl-des-AB-cholest-8-ene p-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine (anhydrous) / methanol / 1.) 0 deg C, 1 h, 2.) room temp., 1 h

2: pyridine / 4 h / Ambient temperature

With hydrazine; In pyridine; methanol;

Reference yield:

: 2763-32-8
3β-methoxy-5β-methyl-19-norcholest-9-en-6-one

: 3752-57-6
8-hydroxymethyl-des-AB-cholest-8-ene p-nitrobenzoate

Guidance literature:: Multi-step reaction with 12 steps

1: lithium di-isopropylamide / tetrahydrofuran

2: 7.55 g / triethylammonium fluoride / CH₂Cl₂ / 3 h / 12 °C

3: 6.80 g / LiAlH₄ / diethyl ether / 1 h / Heating

5: 3.12 g / ozonised oxygen / CH₂Cl₂; methanol / -78 °C

6: 96 percent / t-BuOH, LiAlH₄ / diethyl ether / 3 h / Ambient temperature

7: 93 percent / tri-n-butylphosphine / benzene / 48 h

8: 630 mg / KOH / methanol; benzene / 0.33 h / Heating

9: 600 mg / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

10: 540 mg / pyridinium chlorochromate / 10 h / Ambient temperature

11: 330 mg / basic alumina / diethyl ether

12: 1.) di-isobutylaluminium hydride / 1.) hexane, 0 deg C, 2 h, 2.) pyridine, 23 deg C, 8 h

With aluminum oxide; potassium hydroxide; ozone-containing oxygen; lithium aluminium tetrahydride; diisobutylaluminum hydride; tributylphosphine; triethylamine hydrofluoride; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; tert-butyl alcohol; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;

Reference yield:

: 5600-02-2
6β-hydroxy-3β-methoxy-5β-methyl-19-norcholest-9-ene

: 3752-57-6
8-hydroxymethyl-des-AB-cholest-8-ene p-nitrobenzoate

Guidance literature:: Multi-step reaction with 13 steps

1: 97 percent / Swern's oxidation

2: lithium di-isopropylamide / tetrahydrofuran

3: 7.55 g / triethylammonium fluoride / CH₂Cl₂ / 3 h / 12 °C

4: 6.80 g / LiAlH₄ / diethyl ether / 1 h / Heating

6: 3.12 g / ozonised oxygen / CH₂Cl₂; methanol / -78 °C

7: 96 percent / t-BuOH, LiAlH₄ / diethyl ether / 3 h / Ambient temperature

8: 93 percent / tri-n-butylphosphine / benzene / 48 h

9: 630 mg / KOH / methanol; benzene / 0.33 h / Heating

10: 600 mg / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

11: 540 mg / pyridinium chlorochromate / 10 h / Ambient temperature

12: 330 mg / basic alumina / diethyl ether

13: 1.) di-isobutylaluminium hydride / 1.) hexane, 0 deg C, 2 h, 2.) pyridine, 23 deg C, 8 h

With aluminum oxide; potassium hydroxide; ozone-containing oxygen; lithium aluminium tetrahydride; diisobutylaluminum hydride; tributylphosphine; triethylamine hydrofluoride; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; tert-butyl alcohol; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;