(4-{5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-2-furyl)methanol

Base Information

Chemical Name:(4-{5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-2-furyl)methanol
CAS No.:913828-45-2
Molecular Formula:C₁₈H₁₁F₃N₂O₃S
Molecular Weight:392.358
Hs Code.:

Synonyms:(4-{5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-2-furyl)methanol

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Chemical Property of (4-{5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-2-furyl)methanol

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Technology Process of (4-{5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-2-furyl)methanol

There total 5 articles about (4-{5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-2-furyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1028947-10-5
C₂₄H₂₅F₃N₂O₃SSi

: 913828-45-2
(4-{5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-2-furyl)methanol

Guidance literature:: C₂₄H₂₅F₃N₂O₃SSi; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 60 ℃; for 3h;

With water; In tetrahydrofuran;

Reference yield:

: 913828-42-9
5-({[t-butyl(dimethyl)silyl]oxy}methyl)-3-furaldehyde

: 913828-45-2
(4-{5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-2-furyl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; triethylamine / dichloromethane / 2 h / 20 °C

2: dicyclohexyl-carbodiimide / toluene / 16 h / 90 °C

3: hydroxylamine / ethanol; water / 1 h / 60 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 60 °C

With hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

Reference yield:

: 913828-43-0
5-({[t-butyl(dimethyl)silyl]oxy}methyl)-3-furonitrile

: 913828-45-2
(4-{5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl}-2-furyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine / ethanol; water / 1 h / 60 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 60 °C

With tetrabutyl ammonium fluoride; hydroxylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water;