N-(2-(2-fluorophenyl)-1H-benzo[d]imidazol-6-yl)quinolin-4-amine

Base Information

• Chemical Name: N-(2-(2-fluorophenyl)-1H-benzo[d]imidazol-6-yl)quinolin-4-amine
• CAS No.: 1593834-64-0
• Molecular Formula: C₂₂H₁₅FN₄
• Molecular Weight: 354.386
• Mol file: 1593834-64-0.mol

Synonyms:N-(2-(2-fluorophenyl)-1H-benzo[d]imidazol-6-yl)quinolin-4-amine

Chemical Property of N-(2-(2-fluorophenyl)-1H-benzo[d]imidazol-6-yl)quinolin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(2-fluorophenyl)-1H-benzo[d]imidazol-6-yl)quinolin-4-amine

There total 5 articles about N-(2-(2-fluorophenyl)-1H-benzo[d]imidazol-6-yl)quinolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-(2-fluorophenyl)-1H-benzo[d]imidazol-5-amine + 4-chloroquinoline (611-35-8) → N-(2-(2-fluorophenyl)-1H-benzo[d]imidazol-6-yl)quinolin-4-amine (1593834-64-0)

Guidance literature:

In isopropyl alcohol; for 5h; Reflux;

DOI:10.1016/j.ejmech.2014.07.071

Reference yield:

4-Nitrophenylene-1,2-diamine (99-56-9) → N-(2-(2-fluorophenyl)-1H-benzo[d]imidazol-6-yl)quinolin-4-amine (1593834-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: polyphosphoric acid (PPA) / 5 h / 120 - 150 °C

2: iron; acetic acid / ethanol; water / 2 h / 760.05 Torr / Reflux

3: isopropyl alcohol / 5 h / Reflux

With iron; acetic acid; In ethanol; water; isopropyl alcohol;

DOI:10.1016/j.ejmech.2014.07.071

Reference yield:

o-fluoro-benzoic acid (445-29-4) → N-(2-(2-fluorophenyl)-1H-benzo[d]imidazol-6-yl)quinolin-4-amine (1593834-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: polyphosphoric acid (PPA) / 5 h / 120 - 150 °C

2: iron; acetic acid / ethanol; water / 2 h / 760.05 Torr / Reflux

3: isopropyl alcohol / 5 h / Reflux

With iron; acetic acid; In ethanol; water; isopropyl alcohol;

DOI:10.1016/j.ejmech.2014.07.071

upstream raw materials:

4-Nitrophenylene-1,2-diamine

o-fluoro-benzoic acid

2-(2-fluorophenyl)-5-nitro-1H-benzo[d]imidazole

4-chloroquinoline