1-(CBZ-Tyr-Gly-Gly-Phe)-4-(4-phthalimidobutyryl)-1,4-diazabutane

Base Information

• Chemical Name: 1-(CBZ-Tyr-Gly-Gly-Phe)-4-(4-phthalimidobutyryl)-1,4-diazabutane
• CAS No.: 135646-69-4
• Molecular Formula: C₄₄H₄₇N₇O₁₀
• Molecular Weight: 833.898
• Mol file: 135646-69-4.mol

Synonyms:1-(CBZ-Tyr-Gly-Gly-Phe)-4-(4-phthalimidobutyryl)-1,4-diazabutane

Chemical Property of 1-(CBZ-Tyr-Gly-Gly-Phe)-4-(4-phthalimidobutyryl)-1,4-diazabutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(CBZ-Tyr-Gly-Gly-Phe)-4-(4-phthalimidobutyryl)-1,4-diazabutane

There total 1 articles about 1-(CBZ-Tyr-Gly-Gly-Phe)-4-(4-phthalimidobutyryl)-1,4-diazabutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N-[N-(N-benzyloxycarbonyl-L-tyrosyl)-glycyl]-glycine (74072-21-2) + 1-(phenylalanyl)-4-(4-phthalimidobutyryl)-1,4-diazabutane hydrochloride (135646-66-1) → 1-(CBZ-Tyr-Gly-Gly-Phe)-4-(4-phthalimidobutyryl)-1,4-diazabutane (135646-69-4)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00113a020

Reference yield:

1-(CBZ-Tyr-Gly-Gly-Phe)-4-(4-phthalimidobutyryl)-1,4-diazabutane (135646-69-4) → 1-(Tyr-Gly-Gly-Phe)-4-(4-aminobutyryl)-1,4-diazabutane (135646-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂NNH₂ / ethanol / Heating

2: H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

With hydrogen; hydrazine; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00113a020

Reference yield:

1-(CBZ-Tyr-Gly-Gly-Phe)-4-(4-phthalimidobutyryl)-1,4-diazabutane (135646-69-4) → [(S)-1-({[({(S)-1-[2-(4-Amino-butyrylamino)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid benzyl ester

Guidance literature:

With hydrazine; In ethanol; Heating;

DOI:10.1021/jm00113a020

upstream raw materials:

N-[N-(N-benzyloxycarbonyl-L-tyrosyl)-glycyl]-glycine

1-(phenylalanyl)-4-(4-phthalimidobutyryl)-1,4-diazabutane hydrochloride

Downstream raw materials:

1-(Tyr-Gly-Gly-Phe)-4-(4-aminobutyryl)-1,4-diazabutane