4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyloxymethoxymethyl-2'-O-dimethoxytrityl-β-D-adenosin-5'-O-ylmethanephosphonate

Base Information

Chemical Name:4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyloxymethoxymethyl-2'-O-dimethoxytrityl-β-D-adenosin-5'-O-ylmethanephosphonate
CAS No.:1357015-95-2
Molecular Formula:C₅₅H₅₃N₆O₁₅P
Molecular Weight:1069.03
Hs Code.:

Synonyms:4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyloxymethoxymethyl-2'-O-dimethoxytrityl-β-D-adenosin-5'-O-ylmethanephosphonate

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Chemical Property of 4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyloxymethoxymethyl-2'-O-dimethoxytrityl-β-D-adenosin-5'-O-ylmethanephosphonate

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Technology Process of 4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyloxymethoxymethyl-2'-O-dimethoxytrityl-β-D-adenosin-5'-O-ylmethanephosphonate

There total 6 articles about 4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyloxymethoxymethyl-2'-O-dimethoxytrityl-β-D-adenosin-5'-O-ylmethanephosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₂H₆₀N₇O₁₇P

: 1357015-95-2
4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyloxymethoxymethyl-2'-O-dimethoxytrityl-β-D-adenosin-5'-O-ylmethanephosphonate

Guidance literature:: With thiophenol; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.11.040

Reference yield:

: C₄₈H₄₆N₅O₁₃P

: 1357015-95-2
4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyloxymethoxymethyl-2'-O-dimethoxytrityl-β-D-adenosin-5'-O-ylmethanephosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; 4-methoxypyridine N-oxide; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide / 16 h / 20 °C

2: thiophenol; triethylamine / 1,4-dioxane; N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; 4-methoxypyridine N-oxide; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; thiophenol; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.11.040

Reference yield:

: 1332729-27-7
diisopropyl [1-(6-N-benzoyladenin-9-yl)-3-O-benzoyloxymethoxymethyl-2-O-dimethoxytrityl-β-D-ribofuranos-5-O-yl]methylphosphonate

: 1357015-95-2
4-methoxy-1-oxido-2-pyridylmethyl 6-N-benzoyl-3'-O-benzoyloxymethoxymethyl-2'-O-dimethoxytrityl-β-D-adenosin-5'-O-ylmethanephosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine; trimethylsilyl bromide / acetonitrile / 16 h / 20 °C

2: pyridine; 4-methoxypyridine N-oxide; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide / 16 h / 20 °C

3: thiophenol; triethylamine / 1,4-dioxane; N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; 2,6-dimethylpyridine; 4-methoxypyridine N-oxide; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; trimethylsilyl bromide; thiophenol; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.11.040